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Post‐stroke cognitive deficits rarely come alone: Handling co‐morbidity in lesion‐behaviour mapping

Post‐stroke behavioural symptoms often correlate and systematically co‐occur with each other, either because they share cognitive processes, or because their neural correlates are often damaged together. Thus, neuropsychological symptoms often share variance. Many previous lesion‐behaviour mapping s...

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Detalles Bibliográficos
Autores principales: Sperber, Christoph, Nolingberg, Chloé, Karnath, Hans‐Otto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267998/
https://www.ncbi.nlm.nih.gov/pubmed/31782852
http://dx.doi.org/10.1002/hbm.24885
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author Sperber, Christoph
Nolingberg, Chloé
Karnath, Hans‐Otto
author_facet Sperber, Christoph
Nolingberg, Chloé
Karnath, Hans‐Otto
author_sort Sperber, Christoph
collection PubMed
description Post‐stroke behavioural symptoms often correlate and systematically co‐occur with each other, either because they share cognitive processes, or because their neural correlates are often damaged together. Thus, neuropsychological symptoms often share variance. Many previous lesion‐behaviour mapping studies aimed to methodologically consider this shared variance between neuropsychological variables. A first group of studies controlled the behavioural target variable for the variance explained by one or multiple other variables to obtain a more precise mapping of the target variable. A second group of studies focused on the shared variance of multiple variables itself with the aim to map neural correlates of cognitive processes that are shared between the original variables. In the present study, we tested the validity of these methods by using real lesion data and both real and simulated data sets. We show that the variance that is shared between post‐stroke behavioural variables is ambiguous, and that mapping procedures that consider this variance are prone to biases and artefacts. We discuss under which conditions such procedures could still be used and what alternative approaches exist.
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spelling pubmed-72679982020-06-12 Post‐stroke cognitive deficits rarely come alone: Handling co‐morbidity in lesion‐behaviour mapping Sperber, Christoph Nolingberg, Chloé Karnath, Hans‐Otto Hum Brain Mapp Technical Report Post‐stroke behavioural symptoms often correlate and systematically co‐occur with each other, either because they share cognitive processes, or because their neural correlates are often damaged together. Thus, neuropsychological symptoms often share variance. Many previous lesion‐behaviour mapping studies aimed to methodologically consider this shared variance between neuropsychological variables. A first group of studies controlled the behavioural target variable for the variance explained by one or multiple other variables to obtain a more precise mapping of the target variable. A second group of studies focused on the shared variance of multiple variables itself with the aim to map neural correlates of cognitive processes that are shared between the original variables. In the present study, we tested the validity of these methods by using real lesion data and both real and simulated data sets. We show that the variance that is shared between post‐stroke behavioural variables is ambiguous, and that mapping procedures that consider this variance are prone to biases and artefacts. We discuss under which conditions such procedures could still be used and what alternative approaches exist. John Wiley & Sons, Inc. 2019-11-29 /pmc/articles/PMC7267998/ /pubmed/31782852 http://dx.doi.org/10.1002/hbm.24885 Text en © 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technical Report
Sperber, Christoph
Nolingberg, Chloé
Karnath, Hans‐Otto
Post‐stroke cognitive deficits rarely come alone: Handling co‐morbidity in lesion‐behaviour mapping
title Post‐stroke cognitive deficits rarely come alone: Handling co‐morbidity in lesion‐behaviour mapping
title_full Post‐stroke cognitive deficits rarely come alone: Handling co‐morbidity in lesion‐behaviour mapping
title_fullStr Post‐stroke cognitive deficits rarely come alone: Handling co‐morbidity in lesion‐behaviour mapping
title_full_unstemmed Post‐stroke cognitive deficits rarely come alone: Handling co‐morbidity in lesion‐behaviour mapping
title_short Post‐stroke cognitive deficits rarely come alone: Handling co‐morbidity in lesion‐behaviour mapping
title_sort post‐stroke cognitive deficits rarely come alone: handling co‐morbidity in lesion‐behaviour mapping
topic Technical Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267998/
https://www.ncbi.nlm.nih.gov/pubmed/31782852
http://dx.doi.org/10.1002/hbm.24885
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