Cargando…
White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood
Adolescence is a time period associated with marked brain maturation that coincides with an enhanced risk for onset of psychiatric disorder. White matter tract myelination, a process that continues to unfold throughout adolescence, is reported to be abnormal in several psychiatric disorders. Here, w...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268015/ https://www.ncbi.nlm.nih.gov/pubmed/31661180 http://dx.doi.org/10.1002/hbm.24842 |
_version_ | 1783541526623682560 |
---|---|
author | Vanes, Lucy D. Moutoussis, Michael Ziegler, Gabriel Goodyer, Ian M. Fonagy, Peter Jones, Peter B. Bullmore, Edward T. Dolan, Raymond J. |
author_facet | Vanes, Lucy D. Moutoussis, Michael Ziegler, Gabriel Goodyer, Ian M. Fonagy, Peter Jones, Peter B. Bullmore, Edward T. Dolan, Raymond J. |
author_sort | Vanes, Lucy D. |
collection | PubMed |
description | Adolescence is a time period associated with marked brain maturation that coincides with an enhanced risk for onset of psychiatric disorder. White matter tract myelination, a process that continues to unfold throughout adolescence, is reported to be abnormal in several psychiatric disorders. Here, we ask whether psychiatric vulnerability is linked to aberrant developmental myelination trajectories. We assessed a marker of myelin maturation, using magnetisation transfer (MT) imaging, in 10 major white matter tracts. We then investigated its relationship to the expression of a general psychopathology “p‐factor” in a longitudinal analysis of 293 healthy participants between the ages of 14 and 24. We observed significant longitudinal MT increase across the full age spectrum in anterior thalamic radiation, hippocampal cingulum, dorsal cingulum and superior longitudinal fasciculus. MT increase in the inferior fronto‐occipital fasciculus, inferior longitudinal fasciculus and uncinate fasciculus was pronounced in younger participants but levelled off during the transition into young adulthood. Crucially, longitudinal MT increase in dorsal cingulum and uncinate fasciculus decelerated as a function of mean p‐factor scores over the study period. This suggests that an increased expression of psychopathology is closely linked to lower rates of myelin maturation in selective brain tracts over time. Impaired myelin growth in limbic association fibres may serve as a neural marker for emerging mental illness during the course of adolescence and early adulthood. |
format | Online Article Text |
id | pubmed-7268015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72680152020-06-12 White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood Vanes, Lucy D. Moutoussis, Michael Ziegler, Gabriel Goodyer, Ian M. Fonagy, Peter Jones, Peter B. Bullmore, Edward T. Dolan, Raymond J. Hum Brain Mapp Research Articles Adolescence is a time period associated with marked brain maturation that coincides with an enhanced risk for onset of psychiatric disorder. White matter tract myelination, a process that continues to unfold throughout adolescence, is reported to be abnormal in several psychiatric disorders. Here, we ask whether psychiatric vulnerability is linked to aberrant developmental myelination trajectories. We assessed a marker of myelin maturation, using magnetisation transfer (MT) imaging, in 10 major white matter tracts. We then investigated its relationship to the expression of a general psychopathology “p‐factor” in a longitudinal analysis of 293 healthy participants between the ages of 14 and 24. We observed significant longitudinal MT increase across the full age spectrum in anterior thalamic radiation, hippocampal cingulum, dorsal cingulum and superior longitudinal fasciculus. MT increase in the inferior fronto‐occipital fasciculus, inferior longitudinal fasciculus and uncinate fasciculus was pronounced in younger participants but levelled off during the transition into young adulthood. Crucially, longitudinal MT increase in dorsal cingulum and uncinate fasciculus decelerated as a function of mean p‐factor scores over the study period. This suggests that an increased expression of psychopathology is closely linked to lower rates of myelin maturation in selective brain tracts over time. Impaired myelin growth in limbic association fibres may serve as a neural marker for emerging mental illness during the course of adolescence and early adulthood. John Wiley & Sons, Inc. 2019-10-29 /pmc/articles/PMC7268015/ /pubmed/31661180 http://dx.doi.org/10.1002/hbm.24842 Text en © 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Vanes, Lucy D. Moutoussis, Michael Ziegler, Gabriel Goodyer, Ian M. Fonagy, Peter Jones, Peter B. Bullmore, Edward T. Dolan, Raymond J. White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood |
title | White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood |
title_full | White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood |
title_fullStr | White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood |
title_full_unstemmed | White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood |
title_short | White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood |
title_sort | white matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268015/ https://www.ncbi.nlm.nih.gov/pubmed/31661180 http://dx.doi.org/10.1002/hbm.24842 |
work_keys_str_mv | AT vaneslucyd whitemattertractmyelinmaturationanditsassociationwithgeneralpsychopathologyinadolescenceandearlyadulthood AT moutoussismichael whitemattertractmyelinmaturationanditsassociationwithgeneralpsychopathologyinadolescenceandearlyadulthood AT zieglergabriel whitemattertractmyelinmaturationanditsassociationwithgeneralpsychopathologyinadolescenceandearlyadulthood AT goodyerianm whitemattertractmyelinmaturationanditsassociationwithgeneralpsychopathologyinadolescenceandearlyadulthood AT fonagypeter whitemattertractmyelinmaturationanditsassociationwithgeneralpsychopathologyinadolescenceandearlyadulthood AT jonespeterb whitemattertractmyelinmaturationanditsassociationwithgeneralpsychopathologyinadolescenceandearlyadulthood AT bullmoreedwardt whitemattertractmyelinmaturationanditsassociationwithgeneralpsychopathologyinadolescenceandearlyadulthood AT whitemattertractmyelinmaturationanditsassociationwithgeneralpsychopathologyinadolescenceandearlyadulthood AT dolanraymondj whitemattertractmyelinmaturationanditsassociationwithgeneralpsychopathologyinadolescenceandearlyadulthood |