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Different patterns of cerebral perfusion in SLE patients with and without neuropsychiatric manifestations

To investigate brain perfusion patterns in systemic lupus erythematosus (SLE) patients with and without neuropsychiatric systemic lupus erythematosus (NPSLE and non‐NPSLE, respectively) and to identify biomarkers for the diagnosis of NPSLE using noninvasive three‐dimensional (3D) arterial spin label...

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Autores principales: Zhuo, Zhizheng, Su, Li, Duan, Yunyun, Huang, Jing, Qiu, Xiaolu, Haller, Sven, Li, Haiyun, Zeng, Xiaofeng, Liu, Yaou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268026/
https://www.ncbi.nlm.nih.gov/pubmed/31650651
http://dx.doi.org/10.1002/hbm.24837
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author Zhuo, Zhizheng
Su, Li
Duan, Yunyun
Huang, Jing
Qiu, Xiaolu
Haller, Sven
Li, Haiyun
Zeng, Xiaofeng
Liu, Yaou
author_facet Zhuo, Zhizheng
Su, Li
Duan, Yunyun
Huang, Jing
Qiu, Xiaolu
Haller, Sven
Li, Haiyun
Zeng, Xiaofeng
Liu, Yaou
author_sort Zhuo, Zhizheng
collection PubMed
description To investigate brain perfusion patterns in systemic lupus erythematosus (SLE) patients with and without neuropsychiatric systemic lupus erythematosus (NPSLE and non‐NPSLE, respectively) and to identify biomarkers for the diagnosis of NPSLE using noninvasive three‐dimensional (3D) arterial spin labeling (ASL). Thirty‐one NPSLE and 24 non‐NPSLE patients and 32 age‐ and sex‐matched normal controls (NCs) were recruited. Three‐dimensional ASL‐MRI was applied to quantify cerebral perfusion. Whole brain, gray (GM) and white matter (WM), and voxel‐based analysis (VBA) were performed to explore perfusion characteristics. Correlation analysis was performed to find the relationship between the perfusion measures, lesion volumes, and clinical variables. Receiver operating characteristic (ROC) analysis and support vector machine (SVM) classification were applied to differentiate NPSLE patients from non‐NPSLE patients and healthy controls. Compared to NCs, NPSLE patients showed increased cerebral blood flow (CBF) within WM but decreased CBF within GM, while non‐NPSLE patients showed increased CBF within both GM and WM. Compared to non‐NPSLE patients, NPSLE patients showed significantly reduced CBF in the frontal gyrus, cerebellum, and corpus callosum. CBF within several brain regions such as cingulate and corpus callosum showed significant correlations with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and the Systemic Lupus International Collaborating Clinics (SLICC) damage index scores. ROC analysis showed moderate performance in distinguishing NPSLE from non‐NPSLE patients with AUCs > 0.7, while SVM analysis demonstrated that CBF within the corpus callosum achieved an accuracy of 83.6% in distinguishing NPSLE from non‐NPSLE patients. Different brain perfusion patterns were observed between NPSLE and non‐NPSLE patients. CBF measured by noninvasive 3D ASL could be a useful biomarker for the diagnosis and disease monitoring of NPSLE and non‐NPSLE patients.
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spelling pubmed-72680262020-06-12 Different patterns of cerebral perfusion in SLE patients with and without neuropsychiatric manifestations Zhuo, Zhizheng Su, Li Duan, Yunyun Huang, Jing Qiu, Xiaolu Haller, Sven Li, Haiyun Zeng, Xiaofeng Liu, Yaou Hum Brain Mapp Research Articles To investigate brain perfusion patterns in systemic lupus erythematosus (SLE) patients with and without neuropsychiatric systemic lupus erythematosus (NPSLE and non‐NPSLE, respectively) and to identify biomarkers for the diagnosis of NPSLE using noninvasive three‐dimensional (3D) arterial spin labeling (ASL). Thirty‐one NPSLE and 24 non‐NPSLE patients and 32 age‐ and sex‐matched normal controls (NCs) were recruited. Three‐dimensional ASL‐MRI was applied to quantify cerebral perfusion. Whole brain, gray (GM) and white matter (WM), and voxel‐based analysis (VBA) were performed to explore perfusion characteristics. Correlation analysis was performed to find the relationship between the perfusion measures, lesion volumes, and clinical variables. Receiver operating characteristic (ROC) analysis and support vector machine (SVM) classification were applied to differentiate NPSLE patients from non‐NPSLE patients and healthy controls. Compared to NCs, NPSLE patients showed increased cerebral blood flow (CBF) within WM but decreased CBF within GM, while non‐NPSLE patients showed increased CBF within both GM and WM. Compared to non‐NPSLE patients, NPSLE patients showed significantly reduced CBF in the frontal gyrus, cerebellum, and corpus callosum. CBF within several brain regions such as cingulate and corpus callosum showed significant correlations with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and the Systemic Lupus International Collaborating Clinics (SLICC) damage index scores. ROC analysis showed moderate performance in distinguishing NPSLE from non‐NPSLE patients with AUCs > 0.7, while SVM analysis demonstrated that CBF within the corpus callosum achieved an accuracy of 83.6% in distinguishing NPSLE from non‐NPSLE patients. Different brain perfusion patterns were observed between NPSLE and non‐NPSLE patients. CBF measured by noninvasive 3D ASL could be a useful biomarker for the diagnosis and disease monitoring of NPSLE and non‐NPSLE patients. John Wiley & Sons, Inc. 2019-10-24 /pmc/articles/PMC7268026/ /pubmed/31650651 http://dx.doi.org/10.1002/hbm.24837 Text en © 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Zhuo, Zhizheng
Su, Li
Duan, Yunyun
Huang, Jing
Qiu, Xiaolu
Haller, Sven
Li, Haiyun
Zeng, Xiaofeng
Liu, Yaou
Different patterns of cerebral perfusion in SLE patients with and without neuropsychiatric manifestations
title Different patterns of cerebral perfusion in SLE patients with and without neuropsychiatric manifestations
title_full Different patterns of cerebral perfusion in SLE patients with and without neuropsychiatric manifestations
title_fullStr Different patterns of cerebral perfusion in SLE patients with and without neuropsychiatric manifestations
title_full_unstemmed Different patterns of cerebral perfusion in SLE patients with and without neuropsychiatric manifestations
title_short Different patterns of cerebral perfusion in SLE patients with and without neuropsychiatric manifestations
title_sort different patterns of cerebral perfusion in sle patients with and without neuropsychiatric manifestations
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268026/
https://www.ncbi.nlm.nih.gov/pubmed/31650651
http://dx.doi.org/10.1002/hbm.24837
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