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Anterior cingulate cortex differently modulates frontoparietal functional connectivity between resting‐state and working memory tasks

The brain frontoparietal regions and the functional communications between them are critical in supporting working memory and other executive functions. The functional connectivity between frontoparietal regions are modulated by working memory loads, and are shown to be modulated by a third brain re...

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Detalles Bibliográficos
Autores principales: Di, Xin, Zhang, Heming, Biswal, Bharat B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268054/
https://www.ncbi.nlm.nih.gov/pubmed/31904907
http://dx.doi.org/10.1002/hbm.24912
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author Di, Xin
Zhang, Heming
Biswal, Bharat B
author_facet Di, Xin
Zhang, Heming
Biswal, Bharat B
author_sort Di, Xin
collection PubMed
description The brain frontoparietal regions and the functional communications between them are critical in supporting working memory and other executive functions. The functional connectivity between frontoparietal regions are modulated by working memory loads, and are shown to be modulated by a third brain region in resting‐state. However, it is largely unknown whether the third‐region modulations remain the same during working memory tasks or were largely modulated by task demands. In the current study, we collected functional MRI (fMRI) data when the subjects were performing n‐back tasks and in resting‐state. We first used a block‐designed localizer to define the frontoparietal regions that showed higher activations in the 2‐back than the 1‐back condition. Next, we performed physiophysiological interaction (PPI) analysis using left and right middle frontal gyrus (MFG) and superior parietal lobule (SPL) regions, respectively, in three continuous‐designed runs of resting‐state, 1‐back, and 2‐back conditions. No regions showed consistent modulatory interactions with the seed pairs in the three conditions. Instead, the anterior cingulate cortex (ACC) showed different modulatory interactions with the right MFG and SPL among the three conditions. While the increased activity of the ACC was associated with decreased functional coupling between the right MFG and SPL in resting‐state, it was associated with increased functional coupling in the 2‐back condition. The observed task modulations support the functional significance of the modulations of the ACC on frontoparietal connectivity.
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spelling pubmed-72680542020-06-12 Anterior cingulate cortex differently modulates frontoparietal functional connectivity between resting‐state and working memory tasks Di, Xin Zhang, Heming Biswal, Bharat B Hum Brain Mapp Research Articles The brain frontoparietal regions and the functional communications between them are critical in supporting working memory and other executive functions. The functional connectivity between frontoparietal regions are modulated by working memory loads, and are shown to be modulated by a third brain region in resting‐state. However, it is largely unknown whether the third‐region modulations remain the same during working memory tasks or were largely modulated by task demands. In the current study, we collected functional MRI (fMRI) data when the subjects were performing n‐back tasks and in resting‐state. We first used a block‐designed localizer to define the frontoparietal regions that showed higher activations in the 2‐back than the 1‐back condition. Next, we performed physiophysiological interaction (PPI) analysis using left and right middle frontal gyrus (MFG) and superior parietal lobule (SPL) regions, respectively, in three continuous‐designed runs of resting‐state, 1‐back, and 2‐back conditions. No regions showed consistent modulatory interactions with the seed pairs in the three conditions. Instead, the anterior cingulate cortex (ACC) showed different modulatory interactions with the right MFG and SPL among the three conditions. While the increased activity of the ACC was associated with decreased functional coupling between the right MFG and SPL in resting‐state, it was associated with increased functional coupling in the 2‐back condition. The observed task modulations support the functional significance of the modulations of the ACC on frontoparietal connectivity. John Wiley & Sons, Inc. 2020-01-06 /pmc/articles/PMC7268054/ /pubmed/31904907 http://dx.doi.org/10.1002/hbm.24912 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Di, Xin
Zhang, Heming
Biswal, Bharat B
Anterior cingulate cortex differently modulates frontoparietal functional connectivity between resting‐state and working memory tasks
title Anterior cingulate cortex differently modulates frontoparietal functional connectivity between resting‐state and working memory tasks
title_full Anterior cingulate cortex differently modulates frontoparietal functional connectivity between resting‐state and working memory tasks
title_fullStr Anterior cingulate cortex differently modulates frontoparietal functional connectivity between resting‐state and working memory tasks
title_full_unstemmed Anterior cingulate cortex differently modulates frontoparietal functional connectivity between resting‐state and working memory tasks
title_short Anterior cingulate cortex differently modulates frontoparietal functional connectivity between resting‐state and working memory tasks
title_sort anterior cingulate cortex differently modulates frontoparietal functional connectivity between resting‐state and working memory tasks
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268054/
https://www.ncbi.nlm.nih.gov/pubmed/31904907
http://dx.doi.org/10.1002/hbm.24912
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