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Longitudinal patterns of cortical thinning in multiple sclerosis
In multiple sclerosis (MS), cortical atrophy is correlated with clinical and neuropsychological measures. We aimed to examine the differences in the temporospatial evolution of cortical thickness (CTh) between MS‐subtypes and to study the association of CTh with T2‐weighted white matter lesions (T2L...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268070/ https://www.ncbi.nlm.nih.gov/pubmed/32067281 http://dx.doi.org/10.1002/hbm.24940 |
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author | Tsagkas, Charidimos Chakravarty, M. Mallar Gaetano, Laura Naegelin, Yvonne Amann, Michael Parmar, Katrin Papadopoulou, Athina Wuerfel, Jens Kappos, Ludwig Sprenger, Till Magon, Stefano |
author_facet | Tsagkas, Charidimos Chakravarty, M. Mallar Gaetano, Laura Naegelin, Yvonne Amann, Michael Parmar, Katrin Papadopoulou, Athina Wuerfel, Jens Kappos, Ludwig Sprenger, Till Magon, Stefano |
author_sort | Tsagkas, Charidimos |
collection | PubMed |
description | In multiple sclerosis (MS), cortical atrophy is correlated with clinical and neuropsychological measures. We aimed to examine the differences in the temporospatial evolution of cortical thickness (CTh) between MS‐subtypes and to study the association of CTh with T2‐weighted white matter lesions (T2LV) and clinical progression. Two hundred and forty‐three MS patients (180 relapsing–remitting [RRMS], 51 secondary‐progressive [SPMS], and 12 primary‐progressive [PPMS]) underwent annual clinical (incl. expanded disability status scale [EDSS]) and MRI‐examinations over 6 years. T2LV and CTh were measured. CTh did not differ between MS‐subgroups. Higher total T2LV was associated with extended bilateral CTh‐reduction on average, but did not correlate with CTh‐changes over time. In RRMS, CTh‐ and EDSS‐changes over time were negatively correlated in large bilateral prefrontal, frontal, parietal, temporal, and occipital areas. In SPMS, CTh was not associated with the EDSS. In PPMS, CTh‐ and EDSS‐changes over time were correlated in small clusters predominantly in left parietal areas. Increase of brain lesion load does not lead to an immediate CTh‐reduction. Although CTh did not differ between MS‐subtypes, a dissociation in the correlation between CTh‐ and EDSS‐changes over time between RRMS and progressive‐MS was shown, possibly underlining the contribution of subcortical pathology to clinical progression in progressive‐MS. |
format | Online Article Text |
id | pubmed-7268070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72680702020-06-12 Longitudinal patterns of cortical thinning in multiple sclerosis Tsagkas, Charidimos Chakravarty, M. Mallar Gaetano, Laura Naegelin, Yvonne Amann, Michael Parmar, Katrin Papadopoulou, Athina Wuerfel, Jens Kappos, Ludwig Sprenger, Till Magon, Stefano Hum Brain Mapp Research Articles In multiple sclerosis (MS), cortical atrophy is correlated with clinical and neuropsychological measures. We aimed to examine the differences in the temporospatial evolution of cortical thickness (CTh) between MS‐subtypes and to study the association of CTh with T2‐weighted white matter lesions (T2LV) and clinical progression. Two hundred and forty‐three MS patients (180 relapsing–remitting [RRMS], 51 secondary‐progressive [SPMS], and 12 primary‐progressive [PPMS]) underwent annual clinical (incl. expanded disability status scale [EDSS]) and MRI‐examinations over 6 years. T2LV and CTh were measured. CTh did not differ between MS‐subgroups. Higher total T2LV was associated with extended bilateral CTh‐reduction on average, but did not correlate with CTh‐changes over time. In RRMS, CTh‐ and EDSS‐changes over time were negatively correlated in large bilateral prefrontal, frontal, parietal, temporal, and occipital areas. In SPMS, CTh was not associated with the EDSS. In PPMS, CTh‐ and EDSS‐changes over time were correlated in small clusters predominantly in left parietal areas. Increase of brain lesion load does not lead to an immediate CTh‐reduction. Although CTh did not differ between MS‐subtypes, a dissociation in the correlation between CTh‐ and EDSS‐changes over time between RRMS and progressive‐MS was shown, possibly underlining the contribution of subcortical pathology to clinical progression in progressive‐MS. John Wiley & Sons, Inc. 2020-02-17 /pmc/articles/PMC7268070/ /pubmed/32067281 http://dx.doi.org/10.1002/hbm.24940 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Tsagkas, Charidimos Chakravarty, M. Mallar Gaetano, Laura Naegelin, Yvonne Amann, Michael Parmar, Katrin Papadopoulou, Athina Wuerfel, Jens Kappos, Ludwig Sprenger, Till Magon, Stefano Longitudinal patterns of cortical thinning in multiple sclerosis |
title | Longitudinal patterns of cortical thinning in multiple sclerosis |
title_full | Longitudinal patterns of cortical thinning in multiple sclerosis |
title_fullStr | Longitudinal patterns of cortical thinning in multiple sclerosis |
title_full_unstemmed | Longitudinal patterns of cortical thinning in multiple sclerosis |
title_short | Longitudinal patterns of cortical thinning in multiple sclerosis |
title_sort | longitudinal patterns of cortical thinning in multiple sclerosis |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268070/ https://www.ncbi.nlm.nih.gov/pubmed/32067281 http://dx.doi.org/10.1002/hbm.24940 |
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