Cargando…
Extramedullary disease in acute promyelocytic leukaemia: A rare presentation
Acute promyelocytic leukaemia consists of 7%–8% of cases of acute myeloid leukaemia. Extramedullary manifestations are rare and show distinct biological features. We describe a 22-year-old female of Malay ethnicity who presented with fever and a left axillary swelling for a week. The peripheral bloo...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268156/ https://www.ncbi.nlm.nih.gov/pubmed/32537161 http://dx.doi.org/10.1177/2050313X20926076 |
_version_ | 1783541556557381632 |
---|---|
author | Kasinathan, Ganesh Sathar, Jameela |
author_facet | Kasinathan, Ganesh Sathar, Jameela |
author_sort | Kasinathan, Ganesh |
collection | PubMed |
description | Acute promyelocytic leukaemia consists of 7%–8% of cases of acute myeloid leukaemia. Extramedullary manifestations are rare and show distinct biological features. We describe a 22-year-old female of Malay ethnicity who presented with fever and a left axillary swelling for a week. The peripheral blood smear showed abnormal promyelocytes with faggot cells. PML-RAR-alpha t(15;17) (q22; q12) was detected by polymerase chain reaction. The left axillary swelling histology and immunohistochemical staining confirmed granulocytic sarcoma. She was induced with triple agents consisting of all-trans-retinoic-acid, arsenic trioxide and idarubicin. On day 14 of induction, she developed severe neutropenic sepsis in which she responded to ventilation and antimicrobials. She completed her induction, consolidation and maintenance therapy. Currently she is in molecular and morphological remission. Extramedullary disease in acute promyelocytic leukaemia usually has a severe clinical presentation. Granulocytic sarcoma may present as an early feature of acute promyelocytic leukaemia. |
format | Online Article Text |
id | pubmed-7268156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-72681562020-06-11 Extramedullary disease in acute promyelocytic leukaemia: A rare presentation Kasinathan, Ganesh Sathar, Jameela SAGE Open Med Case Rep Case Report Acute promyelocytic leukaemia consists of 7%–8% of cases of acute myeloid leukaemia. Extramedullary manifestations are rare and show distinct biological features. We describe a 22-year-old female of Malay ethnicity who presented with fever and a left axillary swelling for a week. The peripheral blood smear showed abnormal promyelocytes with faggot cells. PML-RAR-alpha t(15;17) (q22; q12) was detected by polymerase chain reaction. The left axillary swelling histology and immunohistochemical staining confirmed granulocytic sarcoma. She was induced with triple agents consisting of all-trans-retinoic-acid, arsenic trioxide and idarubicin. On day 14 of induction, she developed severe neutropenic sepsis in which she responded to ventilation and antimicrobials. She completed her induction, consolidation and maintenance therapy. Currently she is in molecular and morphological remission. Extramedullary disease in acute promyelocytic leukaemia usually has a severe clinical presentation. Granulocytic sarcoma may present as an early feature of acute promyelocytic leukaemia. SAGE Publications 2020-06-02 /pmc/articles/PMC7268156/ /pubmed/32537161 http://dx.doi.org/10.1177/2050313X20926076 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Kasinathan, Ganesh Sathar, Jameela Extramedullary disease in acute promyelocytic leukaemia: A rare presentation |
title | Extramedullary disease in acute promyelocytic leukaemia: A rare presentation |
title_full | Extramedullary disease in acute promyelocytic leukaemia: A rare presentation |
title_fullStr | Extramedullary disease in acute promyelocytic leukaemia: A rare presentation |
title_full_unstemmed | Extramedullary disease in acute promyelocytic leukaemia: A rare presentation |
title_short | Extramedullary disease in acute promyelocytic leukaemia: A rare presentation |
title_sort | extramedullary disease in acute promyelocytic leukaemia: a rare presentation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268156/ https://www.ncbi.nlm.nih.gov/pubmed/32537161 http://dx.doi.org/10.1177/2050313X20926076 |
work_keys_str_mv | AT kasinathanganesh extramedullarydiseaseinacutepromyelocyticleukaemiaararepresentation AT satharjameela extramedullarydiseaseinacutepromyelocyticleukaemiaararepresentation |