SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines

COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effective therapeutics. Here, we outline the strategies and targets currently adopted in develo...

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Autores principales: Salvatori, Giovanni, Luberto, Laura, Maffei, Mariano, Aurisicchio, Luigi, Roscilli, Giuseppe, Palombo, Fabio, Marra, Emanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268185/
https://www.ncbi.nlm.nih.gov/pubmed/32493510
http://dx.doi.org/10.1186/s12967-020-02392-y
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author Salvatori, Giovanni
Luberto, Laura
Maffei, Mariano
Aurisicchio, Luigi
Roscilli, Giuseppe
Palombo, Fabio
Marra, Emanuele
author_facet Salvatori, Giovanni
Luberto, Laura
Maffei, Mariano
Aurisicchio, Luigi
Roscilli, Giuseppe
Palombo, Fabio
Marra, Emanuele
author_sort Salvatori, Giovanni
collection PubMed
description COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effective therapeutics. Here, we outline the strategies and targets currently adopted in developing a vaccine against SARS-CoV-2. Based on previous evidence and experience with SARS and MERS, the primary focus has been the Spike protein, considered as the ideal target for COVID-19 immunotherapies.
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spelling pubmed-72681852020-06-03 SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines Salvatori, Giovanni Luberto, Laura Maffei, Mariano Aurisicchio, Luigi Roscilli, Giuseppe Palombo, Fabio Marra, Emanuele J Transl Med Commentary COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effective therapeutics. Here, we outline the strategies and targets currently adopted in developing a vaccine against SARS-CoV-2. Based on previous evidence and experience with SARS and MERS, the primary focus has been the Spike protein, considered as the ideal target for COVID-19 immunotherapies. BioMed Central 2020-06-03 /pmc/articles/PMC7268185/ /pubmed/32493510 http://dx.doi.org/10.1186/s12967-020-02392-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Commentary
Salvatori, Giovanni
Luberto, Laura
Maffei, Mariano
Aurisicchio, Luigi
Roscilli, Giuseppe
Palombo, Fabio
Marra, Emanuele
SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines
title SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines
title_full SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines
title_fullStr SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines
title_full_unstemmed SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines
title_short SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines
title_sort sars-cov-2 spike protein: an optimal immunological target for vaccines
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268185/
https://www.ncbi.nlm.nih.gov/pubmed/32493510
http://dx.doi.org/10.1186/s12967-020-02392-y
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