Comparing the effectiveness of magnesium oxide and naldemedine in preventing opioid-induced constipation: a proof of concept, single institutional, two arm, open-label, phase II, randomized controlled trial: the MAGNET study

BACKGROUND: Patients taking opioids are known to develop opioid-induced constipation (OIC), which reduces their quality of life. The aim of this study is to compare magnesium oxide with naldemedine and determine which is more effective in preventing OIC. METHODS: This proof-of-concept, prospective,...

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Detalles Bibliográficos
Autores principales: Ozaki, Anna, Kessoku, Takaomi, Iwaki, Michihiro, Kobayashi, Takashi, Yoshihara, Tsutomu, Kato, Takayuki, Honda, Yasushi, Ogawa, Yuji, Imajo, Kento, Higurashi, Takuma, Yoneda, Masato, Taguri, Masataka, Yamanaka, Takeharu, Ishiki, Hiroto, Kobayashi, Noritoshi, Saito, Satoru, Ichikawa, Yasushi, Nakajima, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268242/
https://www.ncbi.nlm.nih.gov/pubmed/32487150
http://dx.doi.org/10.1186/s13063-020-04385-0

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