GSK-J4 induces cell cycle arrest and apoptosis via ER stress and the synergism between GSK-J4 and decitabine in acute myeloid leukemia KG-1a cells

BACKGROUND: GSK-J4 is the inhibitor of H3K27me3 demethylase. Recent studies demonstrated that GSK-J4 could affect the proliferation and apoptosis of a variety of cancer cells. However, the effects and underlying mechanisms of GSK-J4 on the proliferation and apoptosis of human acute myeloid leukemia...

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Detalles Bibliográficos
Autores principales: Chu, Xuan, Zhong, Liang, Yu, Lihua, Xiong, Ling, Li, Jian, Dan, Wenran, Ye, Jiao, Liu, Chen, Luo, Xu, Liu, Beizhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268296/
https://www.ncbi.nlm.nih.gov/pubmed/32514253
http://dx.doi.org/10.1186/s12935-020-01297-6

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