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Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets

BACKGROUND: Oxidative stress is a key factor that influences piglets’ health. Taurine plays an imperative role in keeping the biological system from damage. This study was conducted to investigate the protective effect of taurine against muscle injury due to the secondary effect of diquat toxicity....

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Autores principales: Wen, Chaoyue, Li, Fengna, Guo, Qiuping, Zhang, Lingyu, Duan, Yehui, Wang, Wenlong, Li, Jianzhong, He, Shanping, Chen, Wen, Yin, Yulong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268319/
https://www.ncbi.nlm.nih.gov/pubmed/32514342
http://dx.doi.org/10.1186/s40104-020-00463-0
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author Wen, Chaoyue
Li, Fengna
Guo, Qiuping
Zhang, Lingyu
Duan, Yehui
Wang, Wenlong
Li, Jianzhong
He, Shanping
Chen, Wen
Yin, Yulong
author_facet Wen, Chaoyue
Li, Fengna
Guo, Qiuping
Zhang, Lingyu
Duan, Yehui
Wang, Wenlong
Li, Jianzhong
He, Shanping
Chen, Wen
Yin, Yulong
author_sort Wen, Chaoyue
collection PubMed
description BACKGROUND: Oxidative stress is a key factor that influences piglets’ health. Taurine plays an imperative role in keeping the biological system from damage. This study was conducted to investigate the protective effect of taurine against muscle injury due to the secondary effect of diquat toxicity. RESULTS: Our study found that taurine effectively and dose-dependently alleviated the diquat toxicity induced rise of feed/gain, with a concurrent improvement of carcass lean percentage. The plasma content of taurine was considerably increased in a dose-dependent manner. Consequently, dietary taurine efficiently improved the activity of plasma antioxidant enzymes. Furthermore, taurine attenuated muscle damage by restoring mitochondrial micromorphology, suppressing protein degradation and reducing the percentage of apoptotic cells in the skeletal muscle. Taurine supplementation also suppressed the genes expression levels of the antioxidant-, mitochondrial biogenesis-, and muscle atrophy-related genes in the skeletal muscle of piglets with oxidative stress. CONCLUSIONS: These results showed that the dose of 0.60% taurine supplementation in the diet could attenuate skeletal muscle injury induced by diquat toxicity. It is suggested that taurine could be a potential nutritional intervention strategy to improve growth performance.
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spelling pubmed-72683192020-06-07 Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets Wen, Chaoyue Li, Fengna Guo, Qiuping Zhang, Lingyu Duan, Yehui Wang, Wenlong Li, Jianzhong He, Shanping Chen, Wen Yin, Yulong J Anim Sci Biotechnol Research BACKGROUND: Oxidative stress is a key factor that influences piglets’ health. Taurine plays an imperative role in keeping the biological system from damage. This study was conducted to investigate the protective effect of taurine against muscle injury due to the secondary effect of diquat toxicity. RESULTS: Our study found that taurine effectively and dose-dependently alleviated the diquat toxicity induced rise of feed/gain, with a concurrent improvement of carcass lean percentage. The plasma content of taurine was considerably increased in a dose-dependent manner. Consequently, dietary taurine efficiently improved the activity of plasma antioxidant enzymes. Furthermore, taurine attenuated muscle damage by restoring mitochondrial micromorphology, suppressing protein degradation and reducing the percentage of apoptotic cells in the skeletal muscle. Taurine supplementation also suppressed the genes expression levels of the antioxidant-, mitochondrial biogenesis-, and muscle atrophy-related genes in the skeletal muscle of piglets with oxidative stress. CONCLUSIONS: These results showed that the dose of 0.60% taurine supplementation in the diet could attenuate skeletal muscle injury induced by diquat toxicity. It is suggested that taurine could be a potential nutritional intervention strategy to improve growth performance. BioMed Central 2020-06-03 /pmc/articles/PMC7268319/ /pubmed/32514342 http://dx.doi.org/10.1186/s40104-020-00463-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wen, Chaoyue
Li, Fengna
Guo, Qiuping
Zhang, Lingyu
Duan, Yehui
Wang, Wenlong
Li, Jianzhong
He, Shanping
Chen, Wen
Yin, Yulong
Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets
title Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets
title_full Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets
title_fullStr Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets
title_full_unstemmed Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets
title_short Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets
title_sort protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268319/
https://www.ncbi.nlm.nih.gov/pubmed/32514342
http://dx.doi.org/10.1186/s40104-020-00463-0
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