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Cerebrospinal fluid penetration of targeted therapeutics in pediatric brain tumor patients

Treatment with small-molecule inhibitors, guided by precision medicine has improved patient outcomes in multiple cancer types. However, these compounds are often not effective against central nervous system (CNS) tumors. The failure of precision medicine approaches for CNS tumors is frequently attri...

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Detalles Bibliográficos
Autores principales:	Guntner, Armin Sebastian, Peyrl, Andreas, Mayr, Lisa, Englinger, Bernhard, Berger, Walter, Slavc, Irene, Buchberger, Wolfgang, Gojo, Johannes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268320/ https://www.ncbi.nlm.nih.gov/pubmed/32493453 http://dx.doi.org/10.1186/s40478-020-00953-2

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