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Changes to aspects of ongoing randomised controlled trials with fixed designs

BACKGROUND: Despite careful planning, changes to some aspects of an ongoing randomised clinical trial (RCT), with a fixed design, may be warranted. We sought to elucidate the distinction between legitimate versus illegitimate changes to serve as a guide for less experienced clinical trialists and ot...

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Detalles Bibliográficos
Autores principales:	Coskinas, Xanthi, Simes, John, Schou, Manjula, Martin, Andrew James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268339/ https://www.ncbi.nlm.nih.gov/pubmed/32493444 http://dx.doi.org/10.1186/s13063-020-04374-3

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