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Global longitudinal strain is associated with better outcomes in transcatheter aortic valve replacement

BACKGROUND: Parameters that mark the timing of left ventricular (LV) reverse remodeling following transcatheter aortic valve replacement (TAVR) are incompletely defined. This study aims to identify the dynamics of LV strain derived from speckle tracking echocardiography in a cohort of patients with...

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Autores principales: Al-Rashid, Fadi, Totzeck, Matthias, Saur, Nadine, Jánosi, Rolf Alexander, Lind, Alexander, Mahabadi, Amir A., Rassaf, Tienush, Mincu, Raluca-Ileana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268397/
https://www.ncbi.nlm.nih.gov/pubmed/32493384
http://dx.doi.org/10.1186/s12872-020-01556-4
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author Al-Rashid, Fadi
Totzeck, Matthias
Saur, Nadine
Jánosi, Rolf Alexander
Lind, Alexander
Mahabadi, Amir A.
Rassaf, Tienush
Mincu, Raluca-Ileana
author_facet Al-Rashid, Fadi
Totzeck, Matthias
Saur, Nadine
Jánosi, Rolf Alexander
Lind, Alexander
Mahabadi, Amir A.
Rassaf, Tienush
Mincu, Raluca-Ileana
author_sort Al-Rashid, Fadi
collection PubMed
description BACKGROUND: Parameters that mark the timing of left ventricular (LV) reverse remodeling following transcatheter aortic valve replacement (TAVR) are incompletely defined. This study aims to identify the dynamics of LV strain derived from speckle tracking echocardiography in a cohort of patients with severe aortic stenosis (AS) who underwent TAVR and its correlation with postprocedural outcomes. METHODS: We selected 150 consecutive patients (82 ± 4 years old, STS score 6.4 ± 6.2) who underwent transfemoral TAVR between 07/2016 and 12/2017 at our tertiary care center. All patients were evaluated at baseline, 1 week after TAVR, and 3 months following TAVR. RESULTS: The global longitudinal strain (GLS) 1 week following TAVR was comparable to that at baseline (− 15,9 ± 4.3 vs − 16.8 ± 4.1; p = NS) but significantly improved at 3 months following TAVR (− 15.9 ± 4.3% vs. -19.5 ± 3.5%; p < 0.001). No significant changes in global circumferential strain (GCS) and global radial strain (GRS) were detectable. The ejection fraction was significantly improved 1 week after the TAVR procedure. The baseline GLS correlated directly with the complication rate (R = 0.36, p = 0.005). The linear regression analysis showed that the main predictors of the improvement in the GLS at 3 months in our cohort were baseline GRS and GCS. CONCLUSION: GLS improves at 3 months after TAVR, while LV ejection fraction does not show a substantial change, signaling an early recovery of LV longitudinal function after the intervention. Additionally, GLS has a direct correlation with the postprocedural outcomes. GLS improvement might emerge as a valuable parameter for a tailored follow-up in TAVR patients.
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spelling pubmed-72683972020-06-07 Global longitudinal strain is associated with better outcomes in transcatheter aortic valve replacement Al-Rashid, Fadi Totzeck, Matthias Saur, Nadine Jánosi, Rolf Alexander Lind, Alexander Mahabadi, Amir A. Rassaf, Tienush Mincu, Raluca-Ileana BMC Cardiovasc Disord Research Article BACKGROUND: Parameters that mark the timing of left ventricular (LV) reverse remodeling following transcatheter aortic valve replacement (TAVR) are incompletely defined. This study aims to identify the dynamics of LV strain derived from speckle tracking echocardiography in a cohort of patients with severe aortic stenosis (AS) who underwent TAVR and its correlation with postprocedural outcomes. METHODS: We selected 150 consecutive patients (82 ± 4 years old, STS score 6.4 ± 6.2) who underwent transfemoral TAVR between 07/2016 and 12/2017 at our tertiary care center. All patients were evaluated at baseline, 1 week after TAVR, and 3 months following TAVR. RESULTS: The global longitudinal strain (GLS) 1 week following TAVR was comparable to that at baseline (− 15,9 ± 4.3 vs − 16.8 ± 4.1; p = NS) but significantly improved at 3 months following TAVR (− 15.9 ± 4.3% vs. -19.5 ± 3.5%; p < 0.001). No significant changes in global circumferential strain (GCS) and global radial strain (GRS) were detectable. The ejection fraction was significantly improved 1 week after the TAVR procedure. The baseline GLS correlated directly with the complication rate (R = 0.36, p = 0.005). The linear regression analysis showed that the main predictors of the improvement in the GLS at 3 months in our cohort were baseline GRS and GCS. CONCLUSION: GLS improves at 3 months after TAVR, while LV ejection fraction does not show a substantial change, signaling an early recovery of LV longitudinal function after the intervention. Additionally, GLS has a direct correlation with the postprocedural outcomes. GLS improvement might emerge as a valuable parameter for a tailored follow-up in TAVR patients. BioMed Central 2020-06-03 /pmc/articles/PMC7268397/ /pubmed/32493384 http://dx.doi.org/10.1186/s12872-020-01556-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Al-Rashid, Fadi
Totzeck, Matthias
Saur, Nadine
Jánosi, Rolf Alexander
Lind, Alexander
Mahabadi, Amir A.
Rassaf, Tienush
Mincu, Raluca-Ileana
Global longitudinal strain is associated with better outcomes in transcatheter aortic valve replacement
title Global longitudinal strain is associated with better outcomes in transcatheter aortic valve replacement
title_full Global longitudinal strain is associated with better outcomes in transcatheter aortic valve replacement
title_fullStr Global longitudinal strain is associated with better outcomes in transcatheter aortic valve replacement
title_full_unstemmed Global longitudinal strain is associated with better outcomes in transcatheter aortic valve replacement
title_short Global longitudinal strain is associated with better outcomes in transcatheter aortic valve replacement
title_sort global longitudinal strain is associated with better outcomes in transcatheter aortic valve replacement
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268397/
https://www.ncbi.nlm.nih.gov/pubmed/32493384
http://dx.doi.org/10.1186/s12872-020-01556-4
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