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The failure of two major formaldehyde catabolism enzymes (ADH5 and ALDH2) leads to partial synthetic lethality in C57BL/6 mice

BACKGROUND: Exogenous formaldehyde is classified by the IARC as a Category 1 known human carcinogen. Meanwhile, a significant amount of endogenous formaldehyde is produced in the human body; as such, formaldehyde-derived DNA and protein adducts have been detected in animals and humans in the absence...

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Detalles Bibliográficos
Autores principales:	Nakamura, Jun, Holley, Darcy W., Kawamoto, Toshihiro, Bultman, Scott J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268536/ https://www.ncbi.nlm.nih.gov/pubmed/32514323 http://dx.doi.org/10.1186/s41021-020-00160-4

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