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Novel therapeutic approaches for treatment of COVID-19

To date, there is no licensed treatment or approved vaccine to combat the coronavirus disease of 2019 (COVID-19), and the number of new cases and mortality multiplies every day. Therefore, it is essential to develop an effective treatment strategy to control the virus spread and prevent the disease....

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Autores principales: Hossein-khannazer, Nikoo, Shokoohian, Bahare, Shpichka, Anastasia, Aghdaei, Hamid Asadzadeh, Timashev, Peter, Vosough, Massoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268974/
https://www.ncbi.nlm.nih.gov/pubmed/32494931
http://dx.doi.org/10.1007/s00109-020-01927-6
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author Hossein-khannazer, Nikoo
Shokoohian, Bahare
Shpichka, Anastasia
Aghdaei, Hamid Asadzadeh
Timashev, Peter
Vosough, Massoud
author_facet Hossein-khannazer, Nikoo
Shokoohian, Bahare
Shpichka, Anastasia
Aghdaei, Hamid Asadzadeh
Timashev, Peter
Vosough, Massoud
author_sort Hossein-khannazer, Nikoo
collection PubMed
description To date, there is no licensed treatment or approved vaccine to combat the coronavirus disease of 2019 (COVID-19), and the number of new cases and mortality multiplies every day. Therefore, it is essential to develop an effective treatment strategy to control the virus spread and prevent the disease. Here, we summarized the therapeutic approaches that are used to treat this infection. Although it seems that antiviral drugs are effective in improving clinical manifestation, there is no definite treatment protocol. Lymphocytopenia, excessive inflammation, and cytokine storm followed by acute respiratory distress syndrome are still unsolved issues causing the severity of this disease. Therefore, immune response modulation and inflammation management can be considered as an essential step. There is no doubt that more studies are required to clarify immunopathogenesis and immune response; however, new therapeutic approaches including mesenchymal stromal cell and immune cell therapy showed inspiring results.
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spelling pubmed-72689742020-06-04 Novel therapeutic approaches for treatment of COVID-19 Hossein-khannazer, Nikoo Shokoohian, Bahare Shpichka, Anastasia Aghdaei, Hamid Asadzadeh Timashev, Peter Vosough, Massoud J Mol Med (Berl) Review To date, there is no licensed treatment or approved vaccine to combat the coronavirus disease of 2019 (COVID-19), and the number of new cases and mortality multiplies every day. Therefore, it is essential to develop an effective treatment strategy to control the virus spread and prevent the disease. Here, we summarized the therapeutic approaches that are used to treat this infection. Although it seems that antiviral drugs are effective in improving clinical manifestation, there is no definite treatment protocol. Lymphocytopenia, excessive inflammation, and cytokine storm followed by acute respiratory distress syndrome are still unsolved issues causing the severity of this disease. Therefore, immune response modulation and inflammation management can be considered as an essential step. There is no doubt that more studies are required to clarify immunopathogenesis and immune response; however, new therapeutic approaches including mesenchymal stromal cell and immune cell therapy showed inspiring results. Springer Berlin Heidelberg 2020-06-03 2020 /pmc/articles/PMC7268974/ /pubmed/32494931 http://dx.doi.org/10.1007/s00109-020-01927-6 Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Hossein-khannazer, Nikoo
Shokoohian, Bahare
Shpichka, Anastasia
Aghdaei, Hamid Asadzadeh
Timashev, Peter
Vosough, Massoud
Novel therapeutic approaches for treatment of COVID-19
title Novel therapeutic approaches for treatment of COVID-19
title_full Novel therapeutic approaches for treatment of COVID-19
title_fullStr Novel therapeutic approaches for treatment of COVID-19
title_full_unstemmed Novel therapeutic approaches for treatment of COVID-19
title_short Novel therapeutic approaches for treatment of COVID-19
title_sort novel therapeutic approaches for treatment of covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268974/
https://www.ncbi.nlm.nih.gov/pubmed/32494931
http://dx.doi.org/10.1007/s00109-020-01927-6
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