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Animal models for emerging coronavirus: progress and new insights

The emergences of coronaviruses have caused a serious global public health problem because their infection in humans caused the severe acute respiratory disease and deaths. The outbreaks of lethal coronaviruses have taken place for three times within recent two decades (SARS-CoV in 2002, MERS-CoV in...

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Autores principales: Yuan, Lunzhi, Tang, Qiyi, Cheng, Tong, Xia, Ningshao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269044/
https://www.ncbi.nlm.nih.gov/pubmed/32378471
http://dx.doi.org/10.1080/22221751.2020.1764871
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author Yuan, Lunzhi
Tang, Qiyi
Cheng, Tong
Xia, Ningshao
author_facet Yuan, Lunzhi
Tang, Qiyi
Cheng, Tong
Xia, Ningshao
author_sort Yuan, Lunzhi
collection PubMed
description The emergences of coronaviruses have caused a serious global public health problem because their infection in humans caused the severe acute respiratory disease and deaths. The outbreaks of lethal coronaviruses have taken place for three times within recent two decades (SARS-CoV in 2002, MERS-CoV in 2012 and SARS-CoV-2 in 2019). Much more serious than SARS-CoV in 2002, the current SARS-CoV-2 infection has been spreading to more than 213 countries, areas or territories and causing more than two million cases up to date (17 April 2020). Unfortunately, no vaccine and specific anti-coronavirus drugs are available at present time. Current clinical treatment at hand is inadequate to suppress viral replication and inflammation, and reverse organ failure. Intensive research efforts have focused on increasing our understanding of viral biology of SARS-CoV-2, improving antiviral therapy and vaccination strategies. The animal models are important for both the fundamental research and drug discovery of coronavirus. This review aims to summarize the animal models currently available for SARS-CoV and MERS-CoV, and their potential use for the study of SARS-CoV-2. We will discuss the benefits and caveats of these animal models and present critical findings that might guide the fundamental studies and urgent treatment of SARS-CoV-2-caused diseases.
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spelling pubmed-72690442020-06-11 Animal models for emerging coronavirus: progress and new insights Yuan, Lunzhi Tang, Qiyi Cheng, Tong Xia, Ningshao Emerg Microbes Infect Review The emergences of coronaviruses have caused a serious global public health problem because their infection in humans caused the severe acute respiratory disease and deaths. The outbreaks of lethal coronaviruses have taken place for three times within recent two decades (SARS-CoV in 2002, MERS-CoV in 2012 and SARS-CoV-2 in 2019). Much more serious than SARS-CoV in 2002, the current SARS-CoV-2 infection has been spreading to more than 213 countries, areas or territories and causing more than two million cases up to date (17 April 2020). Unfortunately, no vaccine and specific anti-coronavirus drugs are available at present time. Current clinical treatment at hand is inadequate to suppress viral replication and inflammation, and reverse organ failure. Intensive research efforts have focused on increasing our understanding of viral biology of SARS-CoV-2, improving antiviral therapy and vaccination strategies. The animal models are important for both the fundamental research and drug discovery of coronavirus. This review aims to summarize the animal models currently available for SARS-CoV and MERS-CoV, and their potential use for the study of SARS-CoV-2. We will discuss the benefits and caveats of these animal models and present critical findings that might guide the fundamental studies and urgent treatment of SARS-CoV-2-caused diseases. Taylor & Francis 2020-05-13 /pmc/articles/PMC7269044/ /pubmed/32378471 http://dx.doi.org/10.1080/22221751.2020.1764871 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Yuan, Lunzhi
Tang, Qiyi
Cheng, Tong
Xia, Ningshao
Animal models for emerging coronavirus: progress and new insights
title Animal models for emerging coronavirus: progress and new insights
title_full Animal models for emerging coronavirus: progress and new insights
title_fullStr Animal models for emerging coronavirus: progress and new insights
title_full_unstemmed Animal models for emerging coronavirus: progress and new insights
title_short Animal models for emerging coronavirus: progress and new insights
title_sort animal models for emerging coronavirus: progress and new insights
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269044/
https://www.ncbi.nlm.nih.gov/pubmed/32378471
http://dx.doi.org/10.1080/22221751.2020.1764871
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