Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster

Confirmative diagnosis of SARS-CoV-2 infections has been challenged due to unsatisfactory positive rate of molecular assays. Here we identified a family cluster of SARS-CoV-2 infections, with five of six family members were SARS-CoV-2-specific immunoglobin serology testing positive, while molecular...

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Autores principales: Xu, Yan, Xiao, Meng, Liu, Xinchao, Xu, Shengyong, Du, Tiekuan, Xu, Jun, Yang, Qiwen, Xu, Yingchun, Han, Yang, Li, Taisheng, Zhu, Huadong, Wang, Mengzhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269047/
https://www.ncbi.nlm.nih.gov/pubmed/32286155
http://dx.doi.org/10.1080/22221751.2020.1752610
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author Xu, Yan
Xiao, Meng
Liu, Xinchao
Xu, Shengyong
Du, Tiekuan
Xu, Jun
Yang, Qiwen
Xu, Yingchun
Han, Yang
Li, Taisheng
Zhu, Huadong
Wang, Mengzhao
author_facet Xu, Yan
Xiao, Meng
Liu, Xinchao
Xu, Shengyong
Du, Tiekuan
Xu, Jun
Yang, Qiwen
Xu, Yingchun
Han, Yang
Li, Taisheng
Zhu, Huadong
Wang, Mengzhao
author_sort Xu, Yan
collection PubMed
description Confirmative diagnosis of SARS-CoV-2 infections has been challenged due to unsatisfactory positive rate of molecular assays. Here we identified a family cluster of SARS-CoV-2 infections, with five of six family members were SARS-CoV-2-specific immunoglobin serology testing positive, while molecular assays only detected two of this five patients even repeated twice. We comprehensively analyzed this familial cluster of cases based on the clinical characteristics, chest CT images, SARS-CoV-2 molecular detection results, and serology testing results. At last, two patients were diagnosed with COVID-19, two were suspected of COVID-19, and two were considered close contacts. Our results emphasized the significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections, especially for COVID-19 close contacts screening.
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spelling pubmed-72690472020-06-11 Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster Xu, Yan Xiao, Meng Liu, Xinchao Xu, Shengyong Du, Tiekuan Xu, Jun Yang, Qiwen Xu, Yingchun Han, Yang Li, Taisheng Zhu, Huadong Wang, Mengzhao Emerg Microbes Infect Letter Confirmative diagnosis of SARS-CoV-2 infections has been challenged due to unsatisfactory positive rate of molecular assays. Here we identified a family cluster of SARS-CoV-2 infections, with five of six family members were SARS-CoV-2-specific immunoglobin serology testing positive, while molecular assays only detected two of this five patients even repeated twice. We comprehensively analyzed this familial cluster of cases based on the clinical characteristics, chest CT images, SARS-CoV-2 molecular detection results, and serology testing results. At last, two patients were diagnosed with COVID-19, two were suspected of COVID-19, and two were considered close contacts. Our results emphasized the significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections, especially for COVID-19 close contacts screening. Taylor & Francis 2020-05-13 /pmc/articles/PMC7269047/ /pubmed/32286155 http://dx.doi.org/10.1080/22221751.2020.1752610 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter
Xu, Yan
Xiao, Meng
Liu, Xinchao
Xu, Shengyong
Du, Tiekuan
Xu, Jun
Yang, Qiwen
Xu, Yingchun
Han, Yang
Li, Taisheng
Zhu, Huadong
Wang, Mengzhao
Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster
title Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster
title_full Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster
title_fullStr Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster
title_full_unstemmed Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster
title_short Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster
title_sort significance of serology testing to assist timely diagnosis of sars-cov-2 infections: implication from a family cluster
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269047/
https://www.ncbi.nlm.nih.gov/pubmed/32286155
http://dx.doi.org/10.1080/22221751.2020.1752610
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