Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection

Increasing evidences suggest that HBsAg-production varies across HBV-genotypes. HBsAg C-terminus plays a crucial role for HBsAg-secretion. Here, we evaluate HBsAg-levels in different HBV-genotypes in HBeAg-negative chronic infection, the correlation of specific mutations in HBsAg C-terminus with HBs...

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Autores principales: Salpini, Romina, Battisti, Arianna, Piermatteo, Lorenzo, Carioti, Luca, Anastasiou, Olympia E., Gill, Upkar S., Di Carlo, Domenico, Colagrossi, Luna, Duca, Leonardo, Bertoli, Ada, La Rosa, Katia Yu, Fabeni, Lavinia, Iuvara, Alessandra, Malagnino, Vincenzo, Cerva, Carlotta, Lichtner, Miriam, Mastroianni, Claudio M., De Sanctis, Giuseppe Maria, Paoloni, Maurizio, Marignani, Massimo, Pasquazzi, Caterina, Iapadre, Nerio, Parruti, Giustino, Vecchiet, Jacopo, Sarmati, Loredana, Andreoni, Massimo, Angelico, Mario, Grelli, Sandro, T. Kennedy, Patrick, Verheyen, Jens, Aquaro, Stefano, Ceccherini-Silberstein, Francesca, Perno, Carlo Federico, Svicher, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269061/
https://www.ncbi.nlm.nih.gov/pubmed/32312174
http://dx.doi.org/10.1080/22221751.2020.1757998

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