RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery

Effective nose-to-brain delivery needs to be developed to treat neurodegenerative diseases. Regulating miR-124 can effectively improve the symptoms of ischemic brain injury and provide a certain protective effect from brain damage after cerebral ischemia. We used rat models of middle cerebral artery...

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Autores principales: Hao, Rubin, Sun, Bixi, Yang, Lihua, Ma, Chun, Li, Shuling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269067/
https://www.ncbi.nlm.nih.gov/pubmed/32400219
http://dx.doi.org/10.1080/10717544.2020.1760960
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author Hao, Rubin
Sun, Bixi
Yang, Lihua
Ma, Chun
Li, Shuling
author_facet Hao, Rubin
Sun, Bixi
Yang, Lihua
Ma, Chun
Li, Shuling
author_sort Hao, Rubin
collection PubMed
description Effective nose-to-brain delivery needs to be developed to treat neurodegenerative diseases. Regulating miR-124 can effectively improve the symptoms of ischemic brain injury and provide a certain protective effect from brain damage after cerebral ischemia. We used rat models of middle cerebral artery occlusion (t-MCAO) with ischemic brain injury, and we delivered RVG29-NPs-miR124 intranasally to treat neurological damage after cerebral ischemia. Rhoa and neurological scores in rats treated by intranasal administration of RVG29-PEG-PLGA/miRNA-124 were significantly lower than those in PEG-PLGA/miRNA-124 nasal administration and RVG29-PLGA/miRNA-124 nasal administration group treated rats. These results indicate that the nose-to-brain delivery of PLGA/miRNA-124 conjugated with PEG and RVG29 alleviated the symptoms of cerebral ischemia-reperfusion injury. Thus, nasal delivery of RVG29-PEG-PLGA/miRNA-124 could be a new method for treating neurodegenerative diseases.
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spelling pubmed-72690672020-06-11 RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery Hao, Rubin Sun, Bixi Yang, Lihua Ma, Chun Li, Shuling Drug Deliv Research Article Effective nose-to-brain delivery needs to be developed to treat neurodegenerative diseases. Regulating miR-124 can effectively improve the symptoms of ischemic brain injury and provide a certain protective effect from brain damage after cerebral ischemia. We used rat models of middle cerebral artery occlusion (t-MCAO) with ischemic brain injury, and we delivered RVG29-NPs-miR124 intranasally to treat neurological damage after cerebral ischemia. Rhoa and neurological scores in rats treated by intranasal administration of RVG29-PEG-PLGA/miRNA-124 were significantly lower than those in PEG-PLGA/miRNA-124 nasal administration and RVG29-PLGA/miRNA-124 nasal administration group treated rats. These results indicate that the nose-to-brain delivery of PLGA/miRNA-124 conjugated with PEG and RVG29 alleviated the symptoms of cerebral ischemia-reperfusion injury. Thus, nasal delivery of RVG29-PEG-PLGA/miRNA-124 could be a new method for treating neurodegenerative diseases. Taylor & Francis 2020-05-13 /pmc/articles/PMC7269067/ /pubmed/32400219 http://dx.doi.org/10.1080/10717544.2020.1760960 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hao, Rubin
Sun, Bixi
Yang, Lihua
Ma, Chun
Li, Shuling
RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery
title RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery
title_full RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery
title_fullStr RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery
title_full_unstemmed RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery
title_short RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery
title_sort rvg29-modified microrna-loaded nanoparticles improve ischemic brain injury by nasal delivery
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269067/
https://www.ncbi.nlm.nih.gov/pubmed/32400219
http://dx.doi.org/10.1080/10717544.2020.1760960
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