Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow

Hepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and/or vira...

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Detalles Bibliográficos
Autores principales: Wang, Lin, Yan, Li, Jiang, Jieling, Zhang, Yuyi, He, Qiyu, Zhuang, Hui, Wang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269076/
https://www.ncbi.nlm.nih.gov/pubmed/32366181
http://dx.doi.org/10.1080/22221751.2020.1761762
Descripción
Sumario:Hepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and/or viral proteins were persistently detected in the bone marrow of both patients. The finding suggests that HEV can replicate in human bone marrow as it may serve as a new target site and reservoir of HEV persistence.

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