Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow

Hepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and/or vira...

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Autores principales: Wang, Lin, Yan, Li, Jiang, Jieling, Zhang, Yuyi, He, Qiyu, Zhuang, Hui, Wang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269076/
https://www.ncbi.nlm.nih.gov/pubmed/32366181
http://dx.doi.org/10.1080/22221751.2020.1761762
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author Wang, Lin
Yan, Li
Jiang, Jieling
Zhang, Yuyi
He, Qiyu
Zhuang, Hui
Wang, Ling
author_facet Wang, Lin
Yan, Li
Jiang, Jieling
Zhang, Yuyi
He, Qiyu
Zhuang, Hui
Wang, Ling
author_sort Wang, Lin
collection PubMed
description Hepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and/or viral proteins were persistently detected in the bone marrow of both patients. The finding suggests that HEV can replicate in human bone marrow as it may serve as a new target site and reservoir of HEV persistence.
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spelling pubmed-72690762020-06-11 Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow Wang, Lin Yan, Li Jiang, Jieling Zhang, Yuyi He, Qiyu Zhuang, Hui Wang, Ling Emerg Microbes Infect Letter Hepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and/or viral proteins were persistently detected in the bone marrow of both patients. The finding suggests that HEV can replicate in human bone marrow as it may serve as a new target site and reservoir of HEV persistence. Taylor & Francis 2020-05-18 /pmc/articles/PMC7269076/ /pubmed/32366181 http://dx.doi.org/10.1080/22221751.2020.1761762 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter
Wang, Lin
Yan, Li
Jiang, Jieling
Zhang, Yuyi
He, Qiyu
Zhuang, Hui
Wang, Ling
Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow
title Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow
title_full Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow
title_fullStr Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow
title_full_unstemmed Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow
title_short Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow
title_sort presence and persistence of hepatitis e virus rna and proteins in human bone marrow
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269076/
https://www.ncbi.nlm.nih.gov/pubmed/32366181
http://dx.doi.org/10.1080/22221751.2020.1761762
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