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Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow
Hepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and/or vira...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269076/ https://www.ncbi.nlm.nih.gov/pubmed/32366181 http://dx.doi.org/10.1080/22221751.2020.1761762 |
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author | Wang, Lin Yan, Li Jiang, Jieling Zhang, Yuyi He, Qiyu Zhuang, Hui Wang, Ling |
author_facet | Wang, Lin Yan, Li Jiang, Jieling Zhang, Yuyi He, Qiyu Zhuang, Hui Wang, Ling |
author_sort | Wang, Lin |
collection | PubMed |
description | Hepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and/or viral proteins were persistently detected in the bone marrow of both patients. The finding suggests that HEV can replicate in human bone marrow as it may serve as a new target site and reservoir of HEV persistence. |
format | Online Article Text |
id | pubmed-7269076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-72690762020-06-11 Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow Wang, Lin Yan, Li Jiang, Jieling Zhang, Yuyi He, Qiyu Zhuang, Hui Wang, Ling Emerg Microbes Infect Letter Hepatitis E virus (HEV) infection is primarily manifesting as acute hepatitis, but extra-hepatic replication and injury are frequently reported. During the study period, we discovered two acute myeloid leukaemia (AML) patients infected with HEV genotype 3 and 4, respectively, and HEV RNA and/or viral proteins were persistently detected in the bone marrow of both patients. The finding suggests that HEV can replicate in human bone marrow as it may serve as a new target site and reservoir of HEV persistence. Taylor & Francis 2020-05-18 /pmc/articles/PMC7269076/ /pubmed/32366181 http://dx.doi.org/10.1080/22221751.2020.1761762 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Letter Wang, Lin Yan, Li Jiang, Jieling Zhang, Yuyi He, Qiyu Zhuang, Hui Wang, Ling Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow |
title | Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow |
title_full | Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow |
title_fullStr | Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow |
title_full_unstemmed | Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow |
title_short | Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow |
title_sort | presence and persistence of hepatitis e virus rna and proteins in human bone marrow |
topic | Letter |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269076/ https://www.ncbi.nlm.nih.gov/pubmed/32366181 http://dx.doi.org/10.1080/22221751.2020.1761762 |
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