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Immunohistochemical detection of Tyrosine Kinase receptor (TrK) in follicular and plexiform ameloblastoma – A novel study

OBJECTIVES: The objective is to analyze the immunohistochemical expression pattern of tyrosine kinase receptor (TrK) in ameloblastoma and to compare the immunohistochemical expression pattern of TrK among the histological types of ameloblastoma, follicular and plexiform patterns. MATERIALS AND METHO...

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Autores principales: Jisha, George Babu, Ilayaraja, Vadivel, Yoithapprabhunath, Thuckanickenpalayam Ragunathan, Ganapathy, Nalliappan, Dineshshankar, Janardhanam, Nirmal, Ramadas Madhavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269298/
https://www.ncbi.nlm.nih.gov/pubmed/32508460
http://dx.doi.org/10.4103/jomfp.JOMFP_220_19
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author Jisha, George Babu
Ilayaraja, Vadivel
Yoithapprabhunath, Thuckanickenpalayam Ragunathan
Ganapathy, Nalliappan
Dineshshankar, Janardhanam
Nirmal, Ramadas Madhavan
author_facet Jisha, George Babu
Ilayaraja, Vadivel
Yoithapprabhunath, Thuckanickenpalayam Ragunathan
Ganapathy, Nalliappan
Dineshshankar, Janardhanam
Nirmal, Ramadas Madhavan
author_sort Jisha, George Babu
collection PubMed
description OBJECTIVES: The objective is to analyze the immunohistochemical expression pattern of tyrosine kinase receptor (TrK) in ameloblastoma and to compare the immunohistochemical expression pattern of TrK among the histological types of ameloblastoma, follicular and plexiform patterns. MATERIALS AND METHODS: Forty ameloblastomas (20 follicular and 20 plexiform) were immunostained with anti-human TrK mouse IgG monoclonal antibody, and the pattern of staining is statistically analyzed. RESULTS: Total 20 (4 follicular and 16 plexiform) out of 40 ameloblastomas showed immunoreactivity to TrK. Only the peripheral preameloblast like tall columnar cells showed reactivity, whereas the stellate reticulum like cells is immunonegative. The staining pattern was membranous in the immunoreactive cells. The Chi-square value for the immunoexpression between follicular and plexiform ameloblastoma was statistically significant with a P < 0.005. The results were studied with the downstream pathways from the literature, and a possible mechanism has been proposed. CONCLUSION: The expression pattern of TrK is found to be more in plexiform ameloblastoma than follicular ameloblastoma.
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spelling pubmed-72692982020-06-05 Immunohistochemical detection of Tyrosine Kinase receptor (TrK) in follicular and plexiform ameloblastoma – A novel study Jisha, George Babu Ilayaraja, Vadivel Yoithapprabhunath, Thuckanickenpalayam Ragunathan Ganapathy, Nalliappan Dineshshankar, Janardhanam Nirmal, Ramadas Madhavan J Oral Maxillofac Pathol Original Article OBJECTIVES: The objective is to analyze the immunohistochemical expression pattern of tyrosine kinase receptor (TrK) in ameloblastoma and to compare the immunohistochemical expression pattern of TrK among the histological types of ameloblastoma, follicular and plexiform patterns. MATERIALS AND METHODS: Forty ameloblastomas (20 follicular and 20 plexiform) were immunostained with anti-human TrK mouse IgG monoclonal antibody, and the pattern of staining is statistically analyzed. RESULTS: Total 20 (4 follicular and 16 plexiform) out of 40 ameloblastomas showed immunoreactivity to TrK. Only the peripheral preameloblast like tall columnar cells showed reactivity, whereas the stellate reticulum like cells is immunonegative. The staining pattern was membranous in the immunoreactive cells. The Chi-square value for the immunoexpression between follicular and plexiform ameloblastoma was statistically significant with a P < 0.005. The results were studied with the downstream pathways from the literature, and a possible mechanism has been proposed. CONCLUSION: The expression pattern of TrK is found to be more in plexiform ameloblastoma than follicular ameloblastoma. Wolters Kluwer - Medknow 2020 2020-05-08 /pmc/articles/PMC7269298/ /pubmed/32508460 http://dx.doi.org/10.4103/jomfp.JOMFP_220_19 Text en Copyright: © 2020 Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Jisha, George Babu
Ilayaraja, Vadivel
Yoithapprabhunath, Thuckanickenpalayam Ragunathan
Ganapathy, Nalliappan
Dineshshankar, Janardhanam
Nirmal, Ramadas Madhavan
Immunohistochemical detection of Tyrosine Kinase receptor (TrK) in follicular and plexiform ameloblastoma – A novel study
title Immunohistochemical detection of Tyrosine Kinase receptor (TrK) in follicular and plexiform ameloblastoma – A novel study
title_full Immunohistochemical detection of Tyrosine Kinase receptor (TrK) in follicular and plexiform ameloblastoma – A novel study
title_fullStr Immunohistochemical detection of Tyrosine Kinase receptor (TrK) in follicular and plexiform ameloblastoma – A novel study
title_full_unstemmed Immunohistochemical detection of Tyrosine Kinase receptor (TrK) in follicular and plexiform ameloblastoma – A novel study
title_short Immunohistochemical detection of Tyrosine Kinase receptor (TrK) in follicular and plexiform ameloblastoma – A novel study
title_sort immunohistochemical detection of tyrosine kinase receptor (trk) in follicular and plexiform ameloblastoma – a novel study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269298/
https://www.ncbi.nlm.nih.gov/pubmed/32508460
http://dx.doi.org/10.4103/jomfp.JOMFP_220_19
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