Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis

Extracellular adenosine triphosphate (eATP) released by damaged cells, and its purinergic receptors, comprise a crucial signaling network after injury. Purinergic receptor P2X7 (P2RX7), a major driver of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation and IL-1β pro...

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Detalles Bibliográficos
Autores principales: Baeza-Raja, Bernat, Goodyear, Andrew, Liu, Xiao, Lam, Kevin, Yamamoto, Lynn, Li, Yingwu, Dodson, G. Steven, Takeuchi, Toshi, Kisseleva, Tatiana, Brenner, David A., Dabbagh, Karim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269334/
https://www.ncbi.nlm.nih.gov/pubmed/32492075
http://dx.doi.org/10.1371/journal.pone.0234038

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