Nonclinical Pharmacokinetics, Protein Binding, and Elimination of KBP-7072, an Aminomethylcycline Antibiotic, in Animal Models

KBP-7072 is a semisynthetic aminomethylcycline with broad-spectrum activity against Gram-positive and Gram-negative pathogens, including multidrug-resistant bacterial strains. The pharmacokinetics (PK) of KBP-7072 after oral and intravenous (i.v.) administrations of single and multiple doses were in...

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Detalles Bibliográficos
Autores principales: Tan, Xiaojuan, Zhang, Min, Liu, Qingmei, Wang, Ping, Zhou, Tian, Zhu, Yuanju, Chen, Bin, Wang, Meng, Xia, Yong, Benn, Vincent, Yang, Fred, Zhang, Jay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269484/
https://www.ncbi.nlm.nih.gov/pubmed/32229494
http://dx.doi.org/10.1128/AAC.00488-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269484/
https://www.ncbi.nlm.nih.gov/pubmed/32229494
http://dx.doi.org/10.1128/AAC.00488-20

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