An Engineered Double Lipid II Binding Motifs-Containing Lantibiotic Displays Potent and Selective Antimicrobial Activity against Enterococcus faecium

Lipid II is an essential precursor for bacterial cell wall biosynthesis and thereby an important target for various antibiotics. Several lanthionine-containing peptide antibiotics target lipid II with lanthionine-stabilized lipid II binding motifs. Here, we used the biosynthesis system of the lantib...

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Detalles Bibliográficos
Autores principales: Zhao, Xinghong, Yin, Zhongqiong, Breukink, Eefjan, Moll, Gert N., Kuipers, Oscar P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Chemistry; Biosynthesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269505/
https://www.ncbi.nlm.nih.gov/pubmed/32179527
http://dx.doi.org/10.1128/AAC.02050-19

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