IL-36γ drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes

Epidermal growth factor receptor (EGFR) and MEK inhibitors (EGFRi/MEKi) are beneficial for the treatment of solid cancers but are frequently associated with severe therapy-limiting acneiform skin toxicities. The underlying molecular mechanisms are poorly understood. Using gene expression profiling w...

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Detalles Bibliográficos
Autores principales: Satoh, Takashi K., Mellett, Mark, Meier-Schiesser, Barbara, Fenini, Gabriele, Otsuka, Atsushi, Beer, Hans-Dietmar, Rordorf, Tamara, Maul, Julia-Tatjana, Hafner, Jürg, Navarini, Alexander A., Contassot, Emmanuel, French, Lars E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269569/
https://www.ncbi.nlm.nih.gov/pubmed/31805013
http://dx.doi.org/10.1172/JCI128678

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