A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia

The drug efflux pump ABCB1 is a key driver of chemoresistance, and high expression predicts treatment failure in acute myeloid leukemia (AML). In this study, we identified and functionally validated the network of enhancers that controls expression of ABCB1. We show that exposure of leukemia cells t...

Descripción completa

Detalles Bibliográficos
Autores principales: Williams, Mark S., Amaral, Fabio M.R., Simeoni, Fabrizio, Somervaille, Tim C.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269587/
https://www.ncbi.nlm.nih.gov/pubmed/31770110
http://dx.doi.org/10.1172/JCI130809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269587/
https://www.ncbi.nlm.nih.gov/pubmed/31770110
http://dx.doi.org/10.1172/JCI130809

Ejemplares similares