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Evaluation of cardiac biomarkers in smokers and non-smokers with chronic periodontitis
OBJECTIVES: The present study aimed to assess the levels of the cardiac biomarkers in smokers versus non-smokers chronic periodontitis (CP) patients and periodontally healthy subjects, also to correlate cardiac biomarkers level with the severity of CP. METHODS: Eighty selected individuals were divid...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Qassim Uninversity
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269625/ https://www.ncbi.nlm.nih.gov/pubmed/32536846 |
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author | Ameen, Mazen Attia, Alaa Moustafa Felimban, Anas Al-Dweghri, Tariq Fattni, Abdulrahman Azab, Ehab Baz, Sameh Dardir, Ahmed |
author_facet | Ameen, Mazen Attia, Alaa Moustafa Felimban, Anas Al-Dweghri, Tariq Fattni, Abdulrahman Azab, Ehab Baz, Sameh Dardir, Ahmed |
author_sort | Ameen, Mazen |
collection | PubMed |
description | OBJECTIVES: The present study aimed to assess the levels of the cardiac biomarkers in smokers versus non-smokers chronic periodontitis (CP) patients and periodontally healthy subjects, also to correlate cardiac biomarkers level with the severity of CP. METHODS: Eighty selected individuals were divided into three groups: Smokers CP (28), non-smokers CP (32), and healthy control subjects (20). The CP evaluated clinically by plaque index (PI), bleeding index (BI), clinical attachment loss (CAL), and pocket depth (PD). Serum levels of cardiac biomarkers were assayed for the following: Aspartate transaminase (AST), alanine transaminase (ALT), troponin-I (Tr-I), creatinine kinase (CK), and lactate dehydrogenase (LDH). RESULTS: The statistical analysis of the investigated biomarkers showed that ALT and AST significantly increased in smokers versus non-smokers CP patients (P ≤ 0.05). In addition, the other biomarkers (Tr-I, CK, and LDH) showed a non-significant increase in smokers compared with non-smokers periodontitis patients (P ≥ 0.05). Furthermore, the mean values of all biomarkers, Tr-I, ALT, AST, LDH, and CK, expressed highly significant comparisons (P ≤ 0.01) in smokers and non-smokers CP patients against healthy subjects. CONCLUSION: The present study suggested that the cardiac biomarkers affected by CP and worse aggravated by the presence of smoking that could play a bidirectional effect on periodontitis and cardiovascular (CV) conditions. Further researches are needed to elucidate the efficacy of periodontal treatment and serum cardiac biomarkers in systemically healthy and diseased CV patients. |
format | Online Article Text |
id | pubmed-7269625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Qassim Uninversity |
record_format | MEDLINE/PubMed |
spelling | pubmed-72696252020-06-11 Evaluation of cardiac biomarkers in smokers and non-smokers with chronic periodontitis Ameen, Mazen Attia, Alaa Moustafa Felimban, Anas Al-Dweghri, Tariq Fattni, Abdulrahman Azab, Ehab Baz, Sameh Dardir, Ahmed Int J Health Sci (Qassim) Original Article OBJECTIVES: The present study aimed to assess the levels of the cardiac biomarkers in smokers versus non-smokers chronic periodontitis (CP) patients and periodontally healthy subjects, also to correlate cardiac biomarkers level with the severity of CP. METHODS: Eighty selected individuals were divided into three groups: Smokers CP (28), non-smokers CP (32), and healthy control subjects (20). The CP evaluated clinically by plaque index (PI), bleeding index (BI), clinical attachment loss (CAL), and pocket depth (PD). Serum levels of cardiac biomarkers were assayed for the following: Aspartate transaminase (AST), alanine transaminase (ALT), troponin-I (Tr-I), creatinine kinase (CK), and lactate dehydrogenase (LDH). RESULTS: The statistical analysis of the investigated biomarkers showed that ALT and AST significantly increased in smokers versus non-smokers CP patients (P ≤ 0.05). In addition, the other biomarkers (Tr-I, CK, and LDH) showed a non-significant increase in smokers compared with non-smokers periodontitis patients (P ≥ 0.05). Furthermore, the mean values of all biomarkers, Tr-I, ALT, AST, LDH, and CK, expressed highly significant comparisons (P ≤ 0.01) in smokers and non-smokers CP patients against healthy subjects. CONCLUSION: The present study suggested that the cardiac biomarkers affected by CP and worse aggravated by the presence of smoking that could play a bidirectional effect on periodontitis and cardiovascular (CV) conditions. Further researches are needed to elucidate the efficacy of periodontal treatment and serum cardiac biomarkers in systemically healthy and diseased CV patients. Qassim Uninversity 2020 /pmc/articles/PMC7269625/ /pubmed/32536846 Text en Copyright: © International Journal of Health Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ameen, Mazen Attia, Alaa Moustafa Felimban, Anas Al-Dweghri, Tariq Fattni, Abdulrahman Azab, Ehab Baz, Sameh Dardir, Ahmed Evaluation of cardiac biomarkers in smokers and non-smokers with chronic periodontitis |
title | Evaluation of cardiac biomarkers in smokers and non-smokers with chronic periodontitis |
title_full | Evaluation of cardiac biomarkers in smokers and non-smokers with chronic periodontitis |
title_fullStr | Evaluation of cardiac biomarkers in smokers and non-smokers with chronic periodontitis |
title_full_unstemmed | Evaluation of cardiac biomarkers in smokers and non-smokers with chronic periodontitis |
title_short | Evaluation of cardiac biomarkers in smokers and non-smokers with chronic periodontitis |
title_sort | evaluation of cardiac biomarkers in smokers and non-smokers with chronic periodontitis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269625/ https://www.ncbi.nlm.nih.gov/pubmed/32536846 |
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