Combinatorial approach of in silico and in vitro evaluation of MLH1 variant associated with Lynch syndrome like metastatic colorectal cancer

Colorectal cancer (CRC) is the third most developing cancer worldwide and Lynch syndrome (LS) accounts for 3–4% of CRC. Genetic alteration in any of DNA mismatch repair (MMR) gene is the major cause of LS that disrupt the normal upstream and downstream MMR events. Germline mutation of MLH1 in hetero...

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Detalles Bibliográficos
Autores principales: Saleem, Komal, Zaib, Tahir, Ji, Wei, Zhang, Chunhui, Qin, Qian, Wang, Yusi, Xu, Lidan, Yu, Hanfei, Zhu, Siqi, Dong, Kexian, Si, Shuhan, Jia, Xueyuan, Wu, Jie, Fu, Songbin, Sun, Wenjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269917/
https://www.ncbi.nlm.nih.gov/pubmed/32432717
http://dx.doi.org/10.1042/BSR20200225

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