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Evaluation of organ function in patients with severe COVID-19 infections

OBJECTIVE: The purpose of our study was to assess organ function in 102 patients with severe COVID-19 infections, using retrospective clinical analysis. MATERIAL AND METHODS: A retrospective analysis was conducted on 102 patients with severe COVID-19 infections. The patients were divided into a surv...

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Autores principales: Zhu, Yingjie, Du, Ziqiang, Zhu, Yanfang, Li, Wenfeng, Miao, Hongjun, Li, Zhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier España, S.L.U. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269959/
https://www.ncbi.nlm.nih.gov/pubmed/32586669
http://dx.doi.org/10.1016/j.medcli.2020.05.012
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author Zhu, Yingjie
Du, Ziqiang
Zhu, Yanfang
Li, Wenfeng
Miao, Hongjun
Li, Zhuo
author_facet Zhu, Yingjie
Du, Ziqiang
Zhu, Yanfang
Li, Wenfeng
Miao, Hongjun
Li, Zhuo
author_sort Zhu, Yingjie
collection PubMed
description OBJECTIVE: The purpose of our study was to assess organ function in 102 patients with severe COVID-19 infections, using retrospective clinical analysis. MATERIAL AND METHODS: A retrospective analysis was conducted on 102 patients with severe COVID-19 infections. The patients were divided into a survival group (n = 73) and a non-survival group (n = 29) according to their prognosis. The age, sex, underlying diseases, clinical laboratory data within 48 h (routine blood tests, ALT, AST, TBIL, ALB, BUN, CR, D-Dimer, PT, APTT, FIB, F VIII:C, CK-MB, CK, and LDH), and ventilation status were collected. The organ functions of these severe COVID-19 patients were assessed by comparing the differences between the two groups. RESULTS: AST, BUN, CR, CK-MB, LDH, and CK in the non-survival group were higher than those in the survival group, and the differences were statistically significant (P < 0.05). D-Dimer, PT, FIB, and F VIII:C in the non-survival group were higher than the values observed in the survival group, and the differences were statistically significant (P < 0.05). PLT, AST, BUN, CR, D-Dimer, PT, FIB, F VIII:C, CK-MB, CK, and LDH predicted the area under the ROC curve (AUC) of the COVID19 endpoint events and were 0.721, 0.854, 0.867, 0.757, 0.699, 0.679, 0.715, 0.811, 0.935, and 0.802, respectively. CONCLUSION: The results showed that there were different degrees of damage to the liver, kidneys, blood coagulation, and heart function in the non-survival group. In addition, PLT, AST, BUN, CR, D-Dimer, PT, FIB, F VIII:C, CK-MB, CK, and LDH had value in evaluating disease prognosis.
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spelling pubmed-72699592020-06-05 Evaluation of organ function in patients with severe COVID-19 infections Zhu, Yingjie Du, Ziqiang Zhu, Yanfang Li, Wenfeng Miao, Hongjun Li, Zhuo Med Clin (Barc) Article OBJECTIVE: The purpose of our study was to assess organ function in 102 patients with severe COVID-19 infections, using retrospective clinical analysis. MATERIAL AND METHODS: A retrospective analysis was conducted on 102 patients with severe COVID-19 infections. The patients were divided into a survival group (n = 73) and a non-survival group (n = 29) according to their prognosis. The age, sex, underlying diseases, clinical laboratory data within 48 h (routine blood tests, ALT, AST, TBIL, ALB, BUN, CR, D-Dimer, PT, APTT, FIB, F VIII:C, CK-MB, CK, and LDH), and ventilation status were collected. The organ functions of these severe COVID-19 patients were assessed by comparing the differences between the two groups. RESULTS: AST, BUN, CR, CK-MB, LDH, and CK in the non-survival group were higher than those in the survival group, and the differences were statistically significant (P < 0.05). D-Dimer, PT, FIB, and F VIII:C in the non-survival group were higher than the values observed in the survival group, and the differences were statistically significant (P < 0.05). PLT, AST, BUN, CR, D-Dimer, PT, FIB, F VIII:C, CK-MB, CK, and LDH predicted the area under the ROC curve (AUC) of the COVID19 endpoint events and were 0.721, 0.854, 0.867, 0.757, 0.699, 0.679, 0.715, 0.811, 0.935, and 0.802, respectively. CONCLUSION: The results showed that there were different degrees of damage to the liver, kidneys, blood coagulation, and heart function in the non-survival group. In addition, PLT, AST, BUN, CR, D-Dimer, PT, FIB, F VIII:C, CK-MB, CK, and LDH had value in evaluating disease prognosis. Elsevier España, S.L.U. 2020-09-11 2020-06-04 /pmc/articles/PMC7269959/ /pubmed/32586669 http://dx.doi.org/10.1016/j.medcli.2020.05.012 Text en © 2020 Elsevier España, S.L.U. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zhu, Yingjie
Du, Ziqiang
Zhu, Yanfang
Li, Wenfeng
Miao, Hongjun
Li, Zhuo
Evaluation of organ function in patients with severe COVID-19 infections
title Evaluation of organ function in patients with severe COVID-19 infections
title_full Evaluation of organ function in patients with severe COVID-19 infections
title_fullStr Evaluation of organ function in patients with severe COVID-19 infections
title_full_unstemmed Evaluation of organ function in patients with severe COVID-19 infections
title_short Evaluation of organ function in patients with severe COVID-19 infections
title_sort evaluation of organ function in patients with severe covid-19 infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269959/
https://www.ncbi.nlm.nih.gov/pubmed/32586669
http://dx.doi.org/10.1016/j.medcli.2020.05.012
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