Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities

Brain-derived neurotrophic factor (BDNF) signals through its high affinity receptor Tropomyosin receptor kinase-B (TrkB) to regulate neuronal development, synapse formation and plasticity. In rodents, genetic disruption of Bdnf and TrkB leads to weight gain and a spectrum of neurobehavioural phenoty...

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Detalles Bibliográficos
Autores principales: Sonoyama, Takuhiro, Stadler, Lukas K. J., Zhu, Mingyan, Keogh, Julia M., Henning, Elana, Hisama, Fuki, Kirwan, Peter, Jura, Magdalena, Blaszczyk, Beata K., DeWitt, David C., Brouwers, Bas, Hyvönen, Marko, Barroso, Inês, Merkle, Florian T., Appleyard, Suzanne M., Wayman, Gary A., Farooqi, I. Sadaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270116/
https://www.ncbi.nlm.nih.gov/pubmed/32493978
http://dx.doi.org/10.1038/s41598-020-65531-x

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