Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases

Oxidative stress is associated with many acute and chronic inflammatory diseases, yet limited treatment is currently available clinically. The development of enzyme-mimicking nanomaterials (nanozymes) with good reactive oxygen species (ROS) scavenging ability and biocompatibility is a promising way...

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Autores principales: Liu, Tengfei, Xiao, Bowen, Xiang, Fei, Tan, Jianglin, Chen, Zhuo, Zhang, Xiaorong, Wu, Chengzhou, Mao, Zhengwei, Luo, Gaoxing, Chen, Xiaoyuan, Deng, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270130/
https://www.ncbi.nlm.nih.gov/pubmed/32493916
http://dx.doi.org/10.1038/s41467-020-16544-7
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author Liu, Tengfei
Xiao, Bowen
Xiang, Fei
Tan, Jianglin
Chen, Zhuo
Zhang, Xiaorong
Wu, Chengzhou
Mao, Zhengwei
Luo, Gaoxing
Chen, Xiaoyuan
Deng, Jun
author_facet Liu, Tengfei
Xiao, Bowen
Xiang, Fei
Tan, Jianglin
Chen, Zhuo
Zhang, Xiaorong
Wu, Chengzhou
Mao, Zhengwei
Luo, Gaoxing
Chen, Xiaoyuan
Deng, Jun
author_sort Liu, Tengfei
collection PubMed
description Oxidative stress is associated with many acute and chronic inflammatory diseases, yet limited treatment is currently available clinically. The development of enzyme-mimicking nanomaterials (nanozymes) with good reactive oxygen species (ROS) scavenging ability and biocompatibility is a promising way for the treatment of ROS-related inflammation. Herein we report a simple and efficient one-step development of ultrasmall Cu(5.4)O nanoparticles (Cu(5.4)O USNPs) with multiple enzyme-mimicking and broad-spectrum ROS scavenging ability for the treatment of ROS-related diseases. Cu(5.4)O USNPs simultaneously possessing catalase-, superoxide dismutase-, and glutathione peroxidase-mimicking enzyme properties exhibit cytoprotective effects against ROS-mediated damage at extremely low dosage and significantly improve treatment outcomes in acute kidney injury, acute liver injury and wound healing. Meanwhile, the ultrasmall size of Cu(5.4)O USNPs enables rapid renal clearance of the nanomaterial, guaranteeing the biocompatibility. The protective effect and good biocompatibility of Cu(5.4)O USNPs will facilitate clinical treatment of ROS-related diseases and enable the development of next-generation nanozymes.
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spelling pubmed-72701302020-06-15 Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases Liu, Tengfei Xiao, Bowen Xiang, Fei Tan, Jianglin Chen, Zhuo Zhang, Xiaorong Wu, Chengzhou Mao, Zhengwei Luo, Gaoxing Chen, Xiaoyuan Deng, Jun Nat Commun Article Oxidative stress is associated with many acute and chronic inflammatory diseases, yet limited treatment is currently available clinically. The development of enzyme-mimicking nanomaterials (nanozymes) with good reactive oxygen species (ROS) scavenging ability and biocompatibility is a promising way for the treatment of ROS-related inflammation. Herein we report a simple and efficient one-step development of ultrasmall Cu(5.4)O nanoparticles (Cu(5.4)O USNPs) with multiple enzyme-mimicking and broad-spectrum ROS scavenging ability for the treatment of ROS-related diseases. Cu(5.4)O USNPs simultaneously possessing catalase-, superoxide dismutase-, and glutathione peroxidase-mimicking enzyme properties exhibit cytoprotective effects against ROS-mediated damage at extremely low dosage and significantly improve treatment outcomes in acute kidney injury, acute liver injury and wound healing. Meanwhile, the ultrasmall size of Cu(5.4)O USNPs enables rapid renal clearance of the nanomaterial, guaranteeing the biocompatibility. The protective effect and good biocompatibility of Cu(5.4)O USNPs will facilitate clinical treatment of ROS-related diseases and enable the development of next-generation nanozymes. Nature Publishing Group UK 2020-06-03 /pmc/articles/PMC7270130/ /pubmed/32493916 http://dx.doi.org/10.1038/s41467-020-16544-7 Text en © This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Liu, Tengfei
Xiao, Bowen
Xiang, Fei
Tan, Jianglin
Chen, Zhuo
Zhang, Xiaorong
Wu, Chengzhou
Mao, Zhengwei
Luo, Gaoxing
Chen, Xiaoyuan
Deng, Jun
Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
title Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
title_full Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
title_fullStr Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
title_full_unstemmed Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
title_short Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
title_sort ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270130/
https://www.ncbi.nlm.nih.gov/pubmed/32493916
http://dx.doi.org/10.1038/s41467-020-16544-7
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