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Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings

PURPOSE: To investigate the epidemiological and clinical characteristics of COVID-19 patients with abnormal imaging findings. METHODS: Patients confirmed with SARS-CoV-2 infection in Zhejiang province from January 17 to February 8 who had undergone CT or X-ray were enrolled. Epidemiological and clin...

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Autores principales: Zhang, Xiaoli, Cai, Huan, Hu, Jianhua, Lian, Jiangshan, Gu, Jueqing, Zhang, Shanyan, Ye, Chanyuan, Lu, Yingfeng, Jin, Ciliang, Yu, Guodong, Jia, Hongyu, Zhang, Yimin, Sheng, Jifang, Li, Lanjuan, Yang, Yida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270493/
https://www.ncbi.nlm.nih.gov/pubmed/32205284
http://dx.doi.org/10.1016/j.ijid.2020.03.040
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author Zhang, Xiaoli
Cai, Huan
Hu, Jianhua
Lian, Jiangshan
Gu, Jueqing
Zhang, Shanyan
Ye, Chanyuan
Lu, Yingfeng
Jin, Ciliang
Yu, Guodong
Jia, Hongyu
Zhang, Yimin
Sheng, Jifang
Li, Lanjuan
Yang, Yida
author_facet Zhang, Xiaoli
Cai, Huan
Hu, Jianhua
Lian, Jiangshan
Gu, Jueqing
Zhang, Shanyan
Ye, Chanyuan
Lu, Yingfeng
Jin, Ciliang
Yu, Guodong
Jia, Hongyu
Zhang, Yimin
Sheng, Jifang
Li, Lanjuan
Yang, Yida
author_sort Zhang, Xiaoli
collection PubMed
description PURPOSE: To investigate the epidemiological and clinical characteristics of COVID-19 patients with abnormal imaging findings. METHODS: Patients confirmed with SARS-CoV-2 infection in Zhejiang province from January 17 to February 8 who had undergone CT or X-ray were enrolled. Epidemiological and clinical data were analyzed among those with abnormal or normal imaging findings. RESULTS: Excluding 72 patients with normal images, 230 of 573 patients showed abnormalities affecting more than two lung lobes. The median radiographic score was 2.0, and there was a negative correlation between that score and the oxygenation index (ρ = −0.657, P < 0.001). Patients with abnormal images were older (46.65 ± 13.82), with a higher rate of coexisting condition (28.8%), a lower rate of exposure history, and longer time between onset and confirmation (5 days) than non-pneumonia patients (all P < 0.05). A higher rate of fever, cough, expectoration and headache, a lower level of lymphocytes, albumin, and serum sodium levels and a higher total bilirubin, creatine kinase, lactate dehydrogenase, and C-reactive protein levels and a lower oxygenation index were observed in pneumonia patients (all P < 0.05). Muscle ache, shortness of breath, nausea and vomiting, lower lymphocytes levels, and higher serum creatinine and radiographic score at admission were predictive factors for the severe/critical subtype. CONCLUSION: Patients with abnormal images have more obvious clinical manifestations and laboratory changes. Combing clinical features and radiographic scores can effectively predict severe/critical types.
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spelling pubmed-72704932020-06-05 Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings Zhang, Xiaoli Cai, Huan Hu, Jianhua Lian, Jiangshan Gu, Jueqing Zhang, Shanyan Ye, Chanyuan Lu, Yingfeng Jin, Ciliang Yu, Guodong Jia, Hongyu Zhang, Yimin Sheng, Jifang Li, Lanjuan Yang, Yida Int J Infect Dis Article PURPOSE: To investigate the epidemiological and clinical characteristics of COVID-19 patients with abnormal imaging findings. METHODS: Patients confirmed with SARS-CoV-2 infection in Zhejiang province from January 17 to February 8 who had undergone CT or X-ray were enrolled. Epidemiological and clinical data were analyzed among those with abnormal or normal imaging findings. RESULTS: Excluding 72 patients with normal images, 230 of 573 patients showed abnormalities affecting more than two lung lobes. The median radiographic score was 2.0, and there was a negative correlation between that score and the oxygenation index (ρ = −0.657, P < 0.001). Patients with abnormal images were older (46.65 ± 13.82), with a higher rate of coexisting condition (28.8%), a lower rate of exposure history, and longer time between onset and confirmation (5 days) than non-pneumonia patients (all P < 0.05). A higher rate of fever, cough, expectoration and headache, a lower level of lymphocytes, albumin, and serum sodium levels and a higher total bilirubin, creatine kinase, lactate dehydrogenase, and C-reactive protein levels and a lower oxygenation index were observed in pneumonia patients (all P < 0.05). Muscle ache, shortness of breath, nausea and vomiting, lower lymphocytes levels, and higher serum creatinine and radiographic score at admission were predictive factors for the severe/critical subtype. CONCLUSION: Patients with abnormal images have more obvious clinical manifestations and laboratory changes. Combing clinical features and radiographic scores can effectively predict severe/critical types. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020-05 2020-03-20 /pmc/articles/PMC7270493/ /pubmed/32205284 http://dx.doi.org/10.1016/j.ijid.2020.03.040 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zhang, Xiaoli
Cai, Huan
Hu, Jianhua
Lian, Jiangshan
Gu, Jueqing
Zhang, Shanyan
Ye, Chanyuan
Lu, Yingfeng
Jin, Ciliang
Yu, Guodong
Jia, Hongyu
Zhang, Yimin
Sheng, Jifang
Li, Lanjuan
Yang, Yida
Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings
title Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings
title_full Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings
title_fullStr Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings
title_full_unstemmed Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings
title_short Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings
title_sort epidemiological, clinical characteristics of cases of sars-cov-2 infection with abnormal imaging findings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270493/
https://www.ncbi.nlm.nih.gov/pubmed/32205284
http://dx.doi.org/10.1016/j.ijid.2020.03.040
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