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The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the most lethal human malignancies. Chemotherapeutic agents, such as sorafenib and lenvatinib, can improve the outcomes of HCC patients. Nevertheless, chemoresistance has become a major hurdle in the effective treatment of HCC. Noncoding RNAs (ncRNAs), includ...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Society of Gene & Cell Therapy
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270498/ https://www.ncbi.nlm.nih.gov/pubmed/32505000 http://dx.doi.org/10.1016/j.omtn.2020.05.011 |
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author | Wang, Man Yu, Fei Chen, Xinzhe Li, Peifeng Wang, Kun |
author_facet | Wang, Man Yu, Fei Chen, Xinzhe Li, Peifeng Wang, Kun |
author_sort | Wang, Man |
collection | PubMed |
description | Hepatocellular carcinoma (HCC) is one of the most lethal human malignancies. Chemotherapeutic agents, such as sorafenib and lenvatinib, can improve the outcomes of HCC patients. Nevertheless, chemoresistance has become a major hurdle in the effective treatment of HCC. Noncoding RNAs (ncRNAs), including mircoRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), have been demonstrated to participate in the onset and progression of HCC. Moreover, multiple lines of evidence have indicated that ncRNAs also play a pivotal role in HCC drug resistance. ncRNAs can regulate drug efflux and metabolism, glucose metabolism, cellular death pathways, and malignant characteristics in HCC. A deeper understanding of the molecular mechanisms responsible for ncRNA-mediated drug resistance in HCC will provide new opportunities for improving the treatment of HCC. In this review, we summarize recent findings on the molecular mechanisms by which ncRNAs regulate HCC chemoresistance, as well as their potential clinical implications in overcoming HCC chemoresistance. |
format | Online Article Text |
id | pubmed-7270498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Society of Gene & Cell Therapy |
record_format | MEDLINE/PubMed |
spelling | pubmed-72704982020-06-08 The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma Wang, Man Yu, Fei Chen, Xinzhe Li, Peifeng Wang, Kun Mol Ther Nucleic Acids Article Hepatocellular carcinoma (HCC) is one of the most lethal human malignancies. Chemotherapeutic agents, such as sorafenib and lenvatinib, can improve the outcomes of HCC patients. Nevertheless, chemoresistance has become a major hurdle in the effective treatment of HCC. Noncoding RNAs (ncRNAs), including mircoRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), have been demonstrated to participate in the onset and progression of HCC. Moreover, multiple lines of evidence have indicated that ncRNAs also play a pivotal role in HCC drug resistance. ncRNAs can regulate drug efflux and metabolism, glucose metabolism, cellular death pathways, and malignant characteristics in HCC. A deeper understanding of the molecular mechanisms responsible for ncRNA-mediated drug resistance in HCC will provide new opportunities for improving the treatment of HCC. In this review, we summarize recent findings on the molecular mechanisms by which ncRNAs regulate HCC chemoresistance, as well as their potential clinical implications in overcoming HCC chemoresistance. American Society of Gene & Cell Therapy 2020-05-15 /pmc/articles/PMC7270498/ /pubmed/32505000 http://dx.doi.org/10.1016/j.omtn.2020.05.011 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Wang, Man Yu, Fei Chen, Xinzhe Li, Peifeng Wang, Kun The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma |
title | The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma |
title_full | The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma |
title_fullStr | The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma |
title_full_unstemmed | The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma |
title_short | The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma |
title_sort | underlying mechanisms of noncoding rnas in the chemoresistance of hepatocellular carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270498/ https://www.ncbi.nlm.nih.gov/pubmed/32505000 http://dx.doi.org/10.1016/j.omtn.2020.05.011 |
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