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The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the most lethal human malignancies. Chemotherapeutic agents, such as sorafenib and lenvatinib, can improve the outcomes of HCC patients. Nevertheless, chemoresistance has become a major hurdle in the effective treatment of HCC. Noncoding RNAs (ncRNAs), includ...

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Detalles Bibliográficos
Autores principales: Wang, Man, Yu, Fei, Chen, Xinzhe, Li, Peifeng, Wang, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270498/
https://www.ncbi.nlm.nih.gov/pubmed/32505000
http://dx.doi.org/10.1016/j.omtn.2020.05.011
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author Wang, Man
Yu, Fei
Chen, Xinzhe
Li, Peifeng
Wang, Kun
author_facet Wang, Man
Yu, Fei
Chen, Xinzhe
Li, Peifeng
Wang, Kun
author_sort Wang, Man
collection PubMed
description Hepatocellular carcinoma (HCC) is one of the most lethal human malignancies. Chemotherapeutic agents, such as sorafenib and lenvatinib, can improve the outcomes of HCC patients. Nevertheless, chemoresistance has become a major hurdle in the effective treatment of HCC. Noncoding RNAs (ncRNAs), including mircoRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), have been demonstrated to participate in the onset and progression of HCC. Moreover, multiple lines of evidence have indicated that ncRNAs also play a pivotal role in HCC drug resistance. ncRNAs can regulate drug efflux and metabolism, glucose metabolism, cellular death pathways, and malignant characteristics in HCC. A deeper understanding of the molecular mechanisms responsible for ncRNA-mediated drug resistance in HCC will provide new opportunities for improving the treatment of HCC. In this review, we summarize recent findings on the molecular mechanisms by which ncRNAs regulate HCC chemoresistance, as well as their potential clinical implications in overcoming HCC chemoresistance.
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spelling pubmed-72704982020-06-08 The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma Wang, Man Yu, Fei Chen, Xinzhe Li, Peifeng Wang, Kun Mol Ther Nucleic Acids Article Hepatocellular carcinoma (HCC) is one of the most lethal human malignancies. Chemotherapeutic agents, such as sorafenib and lenvatinib, can improve the outcomes of HCC patients. Nevertheless, chemoresistance has become a major hurdle in the effective treatment of HCC. Noncoding RNAs (ncRNAs), including mircoRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), have been demonstrated to participate in the onset and progression of HCC. Moreover, multiple lines of evidence have indicated that ncRNAs also play a pivotal role in HCC drug resistance. ncRNAs can regulate drug efflux and metabolism, glucose metabolism, cellular death pathways, and malignant characteristics in HCC. A deeper understanding of the molecular mechanisms responsible for ncRNA-mediated drug resistance in HCC will provide new opportunities for improving the treatment of HCC. In this review, we summarize recent findings on the molecular mechanisms by which ncRNAs regulate HCC chemoresistance, as well as their potential clinical implications in overcoming HCC chemoresistance. American Society of Gene & Cell Therapy 2020-05-15 /pmc/articles/PMC7270498/ /pubmed/32505000 http://dx.doi.org/10.1016/j.omtn.2020.05.011 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Wang, Man
Yu, Fei
Chen, Xinzhe
Li, Peifeng
Wang, Kun
The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma
title The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma
title_full The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma
title_fullStr The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma
title_full_unstemmed The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma
title_short The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma
title_sort underlying mechanisms of noncoding rnas in the chemoresistance of hepatocellular carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270498/
https://www.ncbi.nlm.nih.gov/pubmed/32505000
http://dx.doi.org/10.1016/j.omtn.2020.05.011
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