Promising Effects of Benralizumab on Chronic Eosinophilic Pneumonia

We herein report a case of refractory chronic eosinophilic pneumonia (CEP) complicated with uncontrolled bronchial asthma, in which remission was successfully induced with single dose of benralizumab, a monoclonal antibody against the alpha-chain of the interleukin-5 receptor. Resolution of the pati...

Descripción completa

Detalles Bibliográficos
Autores principales: Isomoto, Kohsuke, Baba, Tomohisa, Sekine, Akimasa, Aiko, Naoto, Ogura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270749/
https://www.ncbi.nlm.nih.gov/pubmed/32009090
http://dx.doi.org/10.2169/internalmedicine.3606-19
_version_ 1783541951670255616
author Isomoto, Kohsuke
Baba, Tomohisa
Sekine, Akimasa
Aiko, Naoto
Ogura, Takashi
author_facet Isomoto, Kohsuke
Baba, Tomohisa
Sekine, Akimasa
Aiko, Naoto
Ogura, Takashi
author_sort Isomoto, Kohsuke
collection PubMed
description We herein report a case of refractory chronic eosinophilic pneumonia (CEP) complicated with uncontrolled bronchial asthma, in which remission was successfully induced with single dose of benralizumab, a monoclonal antibody against the alpha-chain of the interleukin-5 receptor. Resolution of the patient's symptoms and consolidation on chest X-ray were observed at 2 weeks and lasted for 8 weeks after the administration of benralizumab. Benralizumab would be a novel alternative choice of treatment for CEP patients who are at risk of potential toxicity due to long-term corticosteroid therapy.
format Online
Article
Text
id pubmed-7270749
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-72707492020-06-09 Promising Effects of Benralizumab on Chronic Eosinophilic Pneumonia Isomoto, Kohsuke Baba, Tomohisa Sekine, Akimasa Aiko, Naoto Ogura, Takashi Intern Med Case Report We herein report a case of refractory chronic eosinophilic pneumonia (CEP) complicated with uncontrolled bronchial asthma, in which remission was successfully induced with single dose of benralizumab, a monoclonal antibody against the alpha-chain of the interleukin-5 receptor. Resolution of the patient's symptoms and consolidation on chest X-ray were observed at 2 weeks and lasted for 8 weeks after the administration of benralizumab. Benralizumab would be a novel alternative choice of treatment for CEP patients who are at risk of potential toxicity due to long-term corticosteroid therapy. The Japanese Society of Internal Medicine 2020-02-01 2020-05-01 /pmc/articles/PMC7270749/ /pubmed/32009090 http://dx.doi.org/10.2169/internalmedicine.3606-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Isomoto, Kohsuke
Baba, Tomohisa
Sekine, Akimasa
Aiko, Naoto
Ogura, Takashi
Promising Effects of Benralizumab on Chronic Eosinophilic Pneumonia
title Promising Effects of Benralizumab on Chronic Eosinophilic Pneumonia
title_full Promising Effects of Benralizumab on Chronic Eosinophilic Pneumonia
title_fullStr Promising Effects of Benralizumab on Chronic Eosinophilic Pneumonia
title_full_unstemmed Promising Effects of Benralizumab on Chronic Eosinophilic Pneumonia
title_short Promising Effects of Benralizumab on Chronic Eosinophilic Pneumonia
title_sort promising effects of benralizumab on chronic eosinophilic pneumonia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270749/
https://www.ncbi.nlm.nih.gov/pubmed/32009090
http://dx.doi.org/10.2169/internalmedicine.3606-19
work_keys_str_mv AT isomotokohsuke promisingeffectsofbenralizumabonchroniceosinophilicpneumonia
AT babatomohisa promisingeffectsofbenralizumabonchroniceosinophilicpneumonia
AT sekineakimasa promisingeffectsofbenralizumabonchroniceosinophilicpneumonia
AT aikonaoto promisingeffectsofbenralizumabonchroniceosinophilicpneumonia
AT oguratakashi promisingeffectsofbenralizumabonchroniceosinophilicpneumonia

Ejemplares similares