Non-small-cell Lung Cancer with Severe Skin Manifestations Related to Radiation Recall Dermatitis after Atezolizumab Treatment

Radiation recall dermatitis (RRD) is an inflammatory reaction that occurs at previously irradiated skin regions after drug administration. We herein report a patient with non-small-cell lung cancer treated previously with thoracic radiotherapy who developed severe RRD induced by atezolizumab [anti-p...

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Detalles Bibliográficos
Autores principales: Nakashima, Kei, Saruwatari, Koichi, Sato, Ryo, Imamura, Kosuke, Kajihara, Ikko, Fukushima, Satoshi, Saito, Tetsuo, Ishizuka, Shiho, Tamanoi, Daisuke, Jodai, Takayuki, Hamada, Shohei, Tomita, Yusuke, Saeki, Sho, Ichiyasu, Hidenori, Oya, Natsuo, Ihn, Hironobu, Sakagami, Takuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270770/
https://www.ncbi.nlm.nih.gov/pubmed/32051381
http://dx.doi.org/10.2169/internalmedicine.3937-19
Descripción
Sumario:Radiation recall dermatitis (RRD) is an inflammatory reaction that occurs at previously irradiated skin regions after drug administration. We herein report a patient with non-small-cell lung cancer treated previously with thoracic radiotherapy who developed severe RRD induced by atezolizumab [anti-programmed death 1 ligand 1 (PD-L1) antibody]. Immunohistochemistry of the skin biopsy showed dermatitis with infiltration of CD8+ lymphocytes, suggesting that atezolizumab might provoke an immune-related inflammatory reaction at previously irradiated skin regions. When administering anti-PD-L1 antibody to patients who have undergone radiotherapy previously, physicians should carefully monitor the irradiated skin for the potential occurrence of RRD.

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