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Non-small-cell Lung Cancer with Severe Skin Manifestations Related to Radiation Recall Dermatitis after Atezolizumab Treatment
Radiation recall dermatitis (RRD) is an inflammatory reaction that occurs at previously irradiated skin regions after drug administration. We herein report a patient with non-small-cell lung cancer treated previously with thoracic radiotherapy who developed severe RRD induced by atezolizumab [anti-p...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Japanese Society of Internal Medicine
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270770/ https://www.ncbi.nlm.nih.gov/pubmed/32051381 http://dx.doi.org/10.2169/internalmedicine.3937-19 |
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| author | Nakashima, Kei Saruwatari, Koichi Sato, Ryo Imamura, Kosuke Kajihara, Ikko Fukushima, Satoshi Saito, Tetsuo Ishizuka, Shiho Tamanoi, Daisuke Jodai, Takayuki Hamada, Shohei Tomita, Yusuke Saeki, Sho Ichiyasu, Hidenori Oya, Natsuo Ihn, Hironobu Sakagami, Takuro |
| author_facet | Nakashima, Kei Saruwatari, Koichi Sato, Ryo Imamura, Kosuke Kajihara, Ikko Fukushima, Satoshi Saito, Tetsuo Ishizuka, Shiho Tamanoi, Daisuke Jodai, Takayuki Hamada, Shohei Tomita, Yusuke Saeki, Sho Ichiyasu, Hidenori Oya, Natsuo Ihn, Hironobu Sakagami, Takuro |
| author_sort | Nakashima, Kei |
| collection | PubMed |
| description | Radiation recall dermatitis (RRD) is an inflammatory reaction that occurs at previously irradiated skin regions after drug administration. We herein report a patient with non-small-cell lung cancer treated previously with thoracic radiotherapy who developed severe RRD induced by atezolizumab [anti-programmed death 1 ligand 1 (PD-L1) antibody]. Immunohistochemistry of the skin biopsy showed dermatitis with infiltration of CD8+ lymphocytes, suggesting that atezolizumab might provoke an immune-related inflammatory reaction at previously irradiated skin regions. When administering anti-PD-L1 antibody to patients who have undergone radiotherapy previously, physicians should carefully monitor the irradiated skin for the potential occurrence of RRD. |
| format | Online Article Text |
| id | pubmed-7270770 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | The Japanese Society of Internal Medicine |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-72707702020-06-09 Non-small-cell Lung Cancer with Severe Skin Manifestations Related to Radiation Recall Dermatitis after Atezolizumab Treatment Nakashima, Kei Saruwatari, Koichi Sato, Ryo Imamura, Kosuke Kajihara, Ikko Fukushima, Satoshi Saito, Tetsuo Ishizuka, Shiho Tamanoi, Daisuke Jodai, Takayuki Hamada, Shohei Tomita, Yusuke Saeki, Sho Ichiyasu, Hidenori Oya, Natsuo Ihn, Hironobu Sakagami, Takuro Intern Med Case Report Radiation recall dermatitis (RRD) is an inflammatory reaction that occurs at previously irradiated skin regions after drug administration. We herein report a patient with non-small-cell lung cancer treated previously with thoracic radiotherapy who developed severe RRD induced by atezolizumab [anti-programmed death 1 ligand 1 (PD-L1) antibody]. Immunohistochemistry of the skin biopsy showed dermatitis with infiltration of CD8+ lymphocytes, suggesting that atezolizumab might provoke an immune-related inflammatory reaction at previously irradiated skin regions. When administering anti-PD-L1 antibody to patients who have undergone radiotherapy previously, physicians should carefully monitor the irradiated skin for the potential occurrence of RRD. The Japanese Society of Internal Medicine 2020-02-12 2020-05-01 /pmc/articles/PMC7270770/ /pubmed/32051381 http://dx.doi.org/10.2169/internalmedicine.3937-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Case Report Nakashima, Kei Saruwatari, Koichi Sato, Ryo Imamura, Kosuke Kajihara, Ikko Fukushima, Satoshi Saito, Tetsuo Ishizuka, Shiho Tamanoi, Daisuke Jodai, Takayuki Hamada, Shohei Tomita, Yusuke Saeki, Sho Ichiyasu, Hidenori Oya, Natsuo Ihn, Hironobu Sakagami, Takuro Non-small-cell Lung Cancer with Severe Skin Manifestations Related to Radiation Recall Dermatitis after Atezolizumab Treatment |
| title | Non-small-cell Lung Cancer with Severe Skin Manifestations Related to Radiation Recall Dermatitis after Atezolizumab Treatment |
| title_full | Non-small-cell Lung Cancer with Severe Skin Manifestations Related to Radiation Recall Dermatitis after Atezolizumab Treatment |
| title_fullStr | Non-small-cell Lung Cancer with Severe Skin Manifestations Related to Radiation Recall Dermatitis after Atezolizumab Treatment |
| title_full_unstemmed | Non-small-cell Lung Cancer with Severe Skin Manifestations Related to Radiation Recall Dermatitis after Atezolizumab Treatment |
| title_short | Non-small-cell Lung Cancer with Severe Skin Manifestations Related to Radiation Recall Dermatitis after Atezolizumab Treatment |
| title_sort | non-small-cell lung cancer with severe skin manifestations related to radiation recall dermatitis after atezolizumab treatment |
| topic | Case Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270770/ https://www.ncbi.nlm.nih.gov/pubmed/32051381 http://dx.doi.org/10.2169/internalmedicine.3937-19 |
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