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Myalgia and Hematuria in Association with Clonidine and Arginine Administration for Growth Hormone Stimulation Tests
Growth hormone deficiency (GHD) in children has significant impacts on growth and metabolism. Two-agent GH stimulation tests are commonly used to diagnose GHD, and these tests are generally considered safe. We report the case of a 5-year 5-month-old boy with a history of anaplastic ependymoma who un...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270994/ https://www.ncbi.nlm.nih.gov/pubmed/32547619 http://dx.doi.org/10.1155/2020/4827072 |
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author | Glibbery, Meghan Fleming, Adam Chanchlani, Rahul Ajani, Olufemi Abiodun Marchetti, Norma Marr, Alexa Samaan, M. Constantine |
author_facet | Glibbery, Meghan Fleming, Adam Chanchlani, Rahul Ajani, Olufemi Abiodun Marchetti, Norma Marr, Alexa Samaan, M. Constantine |
author_sort | Glibbery, Meghan |
collection | PubMed |
description | Growth hormone deficiency (GHD) in children has significant impacts on growth and metabolism. Two-agent GH stimulation tests are commonly used to diagnose GHD, and these tests are generally considered safe. We report the case of a 5-year 5-month-old boy with a history of anaplastic ependymoma who underwent GH stimulation testing for growth deceleration using clonidine and arginine. He developed bilateral calf myalgia and gross hematuria within 24 hours of the tests. Myalgia and hematuria resolved spontaneously. Importantly, the literature review and database searches for hematuria identified 6 cases with clonidine and 20 cases with arginine. This case highlights an unusual combination of adverse reactions to clonidine and arginine in children undergoing GH stimulation testing to assess for GHD. Pediatric endocrinologists need to be aware of the potential for these side effects to allow appropriate management, and further studies are needed to clarify the mechanisms and frequency of these side effects. We recommend that patients and families need to be counselled about hematuria as an association of GH testing with these medications. |
format | Online Article Text |
id | pubmed-7270994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-72709942020-06-15 Myalgia and Hematuria in Association with Clonidine and Arginine Administration for Growth Hormone Stimulation Tests Glibbery, Meghan Fleming, Adam Chanchlani, Rahul Ajani, Olufemi Abiodun Marchetti, Norma Marr, Alexa Samaan, M. Constantine Case Rep Med Case Report Growth hormone deficiency (GHD) in children has significant impacts on growth and metabolism. Two-agent GH stimulation tests are commonly used to diagnose GHD, and these tests are generally considered safe. We report the case of a 5-year 5-month-old boy with a history of anaplastic ependymoma who underwent GH stimulation testing for growth deceleration using clonidine and arginine. He developed bilateral calf myalgia and gross hematuria within 24 hours of the tests. Myalgia and hematuria resolved spontaneously. Importantly, the literature review and database searches for hematuria identified 6 cases with clonidine and 20 cases with arginine. This case highlights an unusual combination of adverse reactions to clonidine and arginine in children undergoing GH stimulation testing to assess for GHD. Pediatric endocrinologists need to be aware of the potential for these side effects to allow appropriate management, and further studies are needed to clarify the mechanisms and frequency of these side effects. We recommend that patients and families need to be counselled about hematuria as an association of GH testing with these medications. Hindawi 2020-05-26 /pmc/articles/PMC7270994/ /pubmed/32547619 http://dx.doi.org/10.1155/2020/4827072 Text en Copyright © 2020 Meghan Glibbery et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Glibbery, Meghan Fleming, Adam Chanchlani, Rahul Ajani, Olufemi Abiodun Marchetti, Norma Marr, Alexa Samaan, M. Constantine Myalgia and Hematuria in Association with Clonidine and Arginine Administration for Growth Hormone Stimulation Tests |
title | Myalgia and Hematuria in Association with Clonidine and Arginine Administration for Growth Hormone Stimulation Tests |
title_full | Myalgia and Hematuria in Association with Clonidine and Arginine Administration for Growth Hormone Stimulation Tests |
title_fullStr | Myalgia and Hematuria in Association with Clonidine and Arginine Administration for Growth Hormone Stimulation Tests |
title_full_unstemmed | Myalgia and Hematuria in Association with Clonidine and Arginine Administration for Growth Hormone Stimulation Tests |
title_short | Myalgia and Hematuria in Association with Clonidine and Arginine Administration for Growth Hormone Stimulation Tests |
title_sort | myalgia and hematuria in association with clonidine and arginine administration for growth hormone stimulation tests |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270994/ https://www.ncbi.nlm.nih.gov/pubmed/32547619 http://dx.doi.org/10.1155/2020/4827072 |
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