N1-Benzofused Modification of Fluoroquinolones Reduces Activity Against Gram-Negative Bacteria

[Image: see text] The fluoroquinolone class of antibiotics has a well-established structure–activity relationship (SAR) and a long history in the clinic, but the effect of electron-rich benzofused substituents at the N1 position remains poorly explored. Because groups at this position are part of th...

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Detalles Bibliográficos
Autores principales: Laws, Mark, Hind, Charlotte, Favaron, Andrea, Jamshidi, Shirin, Evans, Bonnie, Clifford, Melanie, Sutton, J. Mark, Rahman, Khondaker Miraz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271024/
https://www.ncbi.nlm.nih.gov/pubmed/32548371
http://dx.doi.org/10.1021/acsomega.9b03910

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