Lewis Acid-Catalyzed Enantioselective Friedel–Crafts Alkylation of Pyrrole in Water

[Image: see text] Highly enantioselective Friedel–Crafts alkylation of pyrroles with 2-enoyl-pyridine N-oxides in water/chloroform (10:1) was developed under catalysis of Lewis acid. The Friedel–Crafts alkylation products can be obtained in high yields and excellent enantioselectivities. Moreover, s...

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Detalles Bibliográficos
Autores principales: Sun, Jianan, Gui, Yang, Huang, Yekai, Li, Jindong, Zha, Zhenggen, Yang, Yu, Wang, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271029/
https://www.ncbi.nlm.nih.gov/pubmed/32548375
http://dx.doi.org/10.1021/acsomega.9b04115
Descripción
Sumario:[Image: see text] Highly enantioselective Friedel–Crafts alkylation of pyrroles with 2-enoyl-pyridine N-oxides in water/chloroform (10:1) was developed under catalysis of Lewis acid. The Friedel–Crafts alkylation products can be obtained in high yields and excellent enantioselectivities. Moreover, several control experiments were carried out to study the reaction mechanism.

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