Lewis Acid-Catalyzed Enantioselective Friedel–Crafts Alkylation of Pyrrole in Water

[Image: see text] Highly enantioselective Friedel–Crafts alkylation of pyrroles with 2-enoyl-pyridine N-oxides in water/chloroform (10:1) was developed under catalysis of Lewis acid. The Friedel–Crafts alkylation products can be obtained in high yields and excellent enantioselectivities. Moreover, s...

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Autores principales: Sun, Jianan, Gui, Yang, Huang, Yekai, Li, Jindong, Zha, Zhenggen, Yang, Yu, Wang, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271029/
https://www.ncbi.nlm.nih.gov/pubmed/32548375
http://dx.doi.org/10.1021/acsomega.9b04115
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author Sun, Jianan
Gui, Yang
Huang, Yekai
Li, Jindong
Zha, Zhenggen
Yang, Yu
Wang, Zhiyong
author_facet Sun, Jianan
Gui, Yang
Huang, Yekai
Li, Jindong
Zha, Zhenggen
Yang, Yu
Wang, Zhiyong
author_sort Sun, Jianan
collection PubMed
description [Image: see text] Highly enantioselective Friedel–Crafts alkylation of pyrroles with 2-enoyl-pyridine N-oxides in water/chloroform (10:1) was developed under catalysis of Lewis acid. The Friedel–Crafts alkylation products can be obtained in high yields and excellent enantioselectivities. Moreover, several control experiments were carried out to study the reaction mechanism.
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spelling pubmed-72710292020-06-15 Lewis Acid-Catalyzed Enantioselective Friedel–Crafts Alkylation of Pyrrole in Water Sun, Jianan Gui, Yang Huang, Yekai Li, Jindong Zha, Zhenggen Yang, Yu Wang, Zhiyong ACS Omega [Image: see text] Highly enantioselective Friedel–Crafts alkylation of pyrroles with 2-enoyl-pyridine N-oxides in water/chloroform (10:1) was developed under catalysis of Lewis acid. The Friedel–Crafts alkylation products can be obtained in high yields and excellent enantioselectivities. Moreover, several control experiments were carried out to study the reaction mechanism. American Chemical Society 2020-05-11 /pmc/articles/PMC7271029/ /pubmed/32548375 http://dx.doi.org/10.1021/acsomega.9b04115 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Sun, Jianan
Gui, Yang
Huang, Yekai
Li, Jindong
Zha, Zhenggen
Yang, Yu
Wang, Zhiyong
Lewis Acid-Catalyzed Enantioselective Friedel–Crafts Alkylation of Pyrrole in Water
title Lewis Acid-Catalyzed Enantioselective Friedel–Crafts Alkylation of Pyrrole in Water
title_full Lewis Acid-Catalyzed Enantioselective Friedel–Crafts Alkylation of Pyrrole in Water
title_fullStr Lewis Acid-Catalyzed Enantioselective Friedel–Crafts Alkylation of Pyrrole in Water
title_full_unstemmed Lewis Acid-Catalyzed Enantioselective Friedel–Crafts Alkylation of Pyrrole in Water
title_short Lewis Acid-Catalyzed Enantioselective Friedel–Crafts Alkylation of Pyrrole in Water
title_sort lewis acid-catalyzed enantioselective friedel–crafts alkylation of pyrrole in water
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271029/
https://www.ncbi.nlm.nih.gov/pubmed/32548375
http://dx.doi.org/10.1021/acsomega.9b04115
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