JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice

Multiple myeloma (MM) patients develop osteolysis characterised by excessive osteoclastic bone destruction and lack of osteoblast bone formation. Pharmacological manipulation of monoacylglycerol lipase (MAGL), an enzyme responsible for the degradation of the endocannabinoid 2-arachidonoyl glycerol (...

Descripción completa

Detalles Bibliográficos
Autores principales: Marino, Silvia, Carrasco, Giovana, Li, Boya, Shah, Karan M., Lath, Darren L., Sophocleous, Antonia, Lawson, Michelle A., Idris, Aymen I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271071/
https://www.ncbi.nlm.nih.gov/pubmed/32285169
http://dx.doi.org/10.1007/s00223-020-00689-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271071/
https://www.ncbi.nlm.nih.gov/pubmed/32285169
http://dx.doi.org/10.1007/s00223-020-00689-0

Ejemplares similares