COVID-19 vaccines: neutralizing antibodies and the alum advantage

Achieving high levels of neutralizing antibodies to the spike protein of SARS-CoV-2 in a safe manner is likely to be crucial for an effective vaccine. Here, we propose that aluminium-based adjuvants might hold the key to this.

Detalles Bibliográficos
Autores principales: Hotez, Peter J., Corry, David B., Strych, Ulrich, Bottazzi, Maria Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271131/
https://www.ncbi.nlm.nih.gov/pubmed/32499636
http://dx.doi.org/10.1038/s41577-020-0358-6
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author Hotez, Peter J.
Corry, David B.
Strych, Ulrich
Bottazzi, Maria Elena
author_facet Hotez, Peter J.
Corry, David B.
Strych, Ulrich
Bottazzi, Maria Elena
author_sort Hotez, Peter J.
collection PubMed
description Achieving high levels of neutralizing antibodies to the spike protein of SARS-CoV-2 in a safe manner is likely to be crucial for an effective vaccine. Here, we propose that aluminium-based adjuvants might hold the key to this.
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spelling pubmed-72711312020-06-04 COVID-19 vaccines: neutralizing antibodies and the alum advantage Hotez, Peter J. Corry, David B. Strych, Ulrich Bottazzi, Maria Elena Nat Rev Immunol Comment Achieving high levels of neutralizing antibodies to the spike protein of SARS-CoV-2 in a safe manner is likely to be crucial for an effective vaccine. Here, we propose that aluminium-based adjuvants might hold the key to this. Nature Publishing Group UK 2020-06-04 2020 /pmc/articles/PMC7271131/ /pubmed/32499636 http://dx.doi.org/10.1038/s41577-020-0358-6 Text en © Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Hotez, Peter J.
Corry, David B.
Strych, Ulrich
Bottazzi, Maria Elena
COVID-19 vaccines: neutralizing antibodies and the alum advantage
title COVID-19 vaccines: neutralizing antibodies and the alum advantage
title_full COVID-19 vaccines: neutralizing antibodies and the alum advantage
title_fullStr COVID-19 vaccines: neutralizing antibodies and the alum advantage
title_full_unstemmed COVID-19 vaccines: neutralizing antibodies and the alum advantage
title_short COVID-19 vaccines: neutralizing antibodies and the alum advantage
title_sort covid-19 vaccines: neutralizing antibodies and the alum advantage
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271131/
https://www.ncbi.nlm.nih.gov/pubmed/32499636
http://dx.doi.org/10.1038/s41577-020-0358-6
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