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Foldamers in Medicinal Chemistry
Bio-inspired synthetic backbones leading to foldamers can provide effective biopolymer mimics with new and improved properties in a physiological environment, and in turn could serve as useful tools to study biology and lead to practical applications in the areas of diagnostics or therapeutics. Rema...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271180/ http://dx.doi.org/10.1016/B978-0-12-409547-2.12565-X |
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author | Pasco, M. Dolain, C. Guichard, G. |
author_facet | Pasco, M. Dolain, C. Guichard, G. |
author_sort | Pasco, M. |
collection | PubMed |
description | Bio-inspired synthetic backbones leading to foldamers can provide effective biopolymer mimics with new and improved properties in a physiological environment, and in turn could serve as useful tools to study biology and lead to practical applications in the areas of diagnostics or therapeutics. Remarkable progress has been accomplished over the past 20 years with the discovery of many potent bioactive foldamers originating from diverse backbones and targeting a whole spectrum of bio(macro)molecules such as membranes, protein surfaces, and nucleic acids. These current achievements, future opportunities, and key challenges that remain are discussed in this article. |
format | Online Article Text |
id | pubmed-7271180 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
record_format | MEDLINE/PubMed |
spelling | pubmed-72711802020-06-05 Foldamers in Medicinal Chemistry Pasco, M. Dolain, C. Guichard, G. Comprehensive Supramolecular Chemistry II Article Bio-inspired synthetic backbones leading to foldamers can provide effective biopolymer mimics with new and improved properties in a physiological environment, and in turn could serve as useful tools to study biology and lead to practical applications in the areas of diagnostics or therapeutics. Remarkable progress has been accomplished over the past 20 years with the discovery of many potent bioactive foldamers originating from diverse backbones and targeting a whole spectrum of bio(macro)molecules such as membranes, protein surfaces, and nucleic acids. These current achievements, future opportunities, and key challenges that remain are discussed in this article. 2017 2017-06-29 /pmc/articles/PMC7271180/ http://dx.doi.org/10.1016/B978-0-12-409547-2.12565-X Text en Copyright © 2017 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Pasco, M. Dolain, C. Guichard, G. Foldamers in Medicinal Chemistry |
title | Foldamers in Medicinal Chemistry |
title_full | Foldamers in Medicinal Chemistry |
title_fullStr | Foldamers in Medicinal Chemistry |
title_full_unstemmed | Foldamers in Medicinal Chemistry |
title_short | Foldamers in Medicinal Chemistry |
title_sort | foldamers in medicinal chemistry |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271180/ http://dx.doi.org/10.1016/B978-0-12-409547-2.12565-X |
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