Cholesterol Induces Nrf-2- and HIF-1α-Dependent Hepatocyte Proliferation and Liver Regeneration to Ameliorate Bile Acid Toxicity in Mouse Models of NASH and Fibrosis

Nonalcoholic steatohepatitis (NASH) is currently one of the most common liver diseases worldwide. The toxic effects of lipids and bile acids contribute to NASH. The regenerative pathway in response to damage to the liver includes activation of the inflammatory process and priming of hepatocytes to p...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaminsky-Kolesnikov, Yula, Rauchbach, Einat, Abu-Halaka, Diana, Hahn, Michal, García-Ruiz, Carmen, Fernandez-Checa, Jose C., Madar, Zecharia, Tirosh, Oren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271232/
https://www.ncbi.nlm.nih.gov/pubmed/32566088
http://dx.doi.org/10.1155/2020/5393761

Ejemplares similares

Ejemplares similares