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In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in mice

Mutations disrupting regulatory T (Treg) cell function can cause IPEX and IPEX-related disorders, but whether established disease can be reversed by correcting these mutations is unclear. Treg-specific deletion of the chromatin remodeling factor Brg1 impairs Treg cell activation and causes fatal aut...

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Detalles Bibliográficos
Autores principales:	Li, Yongqin, Chen, Yuxin, Mao, Shaoshuai, Kaundal, Ravinder, Jing, Zhengyu, Chen, Qin, Wang, Xinxin, Xia, Jing, Liu, Dahai, Sun, Jianlong, Wang, Haopeng, Chi, Tian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271236/ https://www.ncbi.nlm.nih.gov/pubmed/32493900 http://dx.doi.org/10.1038/s41467-020-15836-2

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