Successful Detection of Unrecognized Rickettsia typhi in Pregnancy Using Cell-Free Next-Generation Sequencing

Flea-borne (murine) typhus is caused by Rickettsia typhi. Infection in pregnant women can lead to adverse outcomes when diagnosis and treatment is delayed. We describe how next-generation sequencing (NGS) using the Karius® test was used to rapidly diagnose murine typhus in two pregnant women admitte...

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Detalles Bibliográficos
Autores principales: Stafford, Irene A., Centeno, Fernando H., Al Mohajer, Mayar, Parkerson, George, Woc-Colburn, Laila, Burgos-Lee, Angelica Janice, Rac, Martha, Dunn, James, Muldrew, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271245/
https://www.ncbi.nlm.nih.gov/pubmed/32547799
http://dx.doi.org/10.1155/2020/6767351
Descripción
Sumario:Flea-borne (murine) typhus is caused by Rickettsia typhi. Infection in pregnant women can lead to adverse outcomes when diagnosis and treatment is delayed. We describe how next-generation sequencing (NGS) using the Karius® test was used to rapidly diagnose murine typhus in two pregnant women admitted to a large tertiary care center in Houston, Texas, when all initial testing was nondiagnostic.

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