Successful Detection of Unrecognized Rickettsia typhi in Pregnancy Using Cell-Free Next-Generation Sequencing

Flea-borne (murine) typhus is caused by Rickettsia typhi. Infection in pregnant women can lead to adverse outcomes when diagnosis and treatment is delayed. We describe how next-generation sequencing (NGS) using the Karius® test was used to rapidly diagnose murine typhus in two pregnant women admitte...

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Autores principales: Stafford, Irene A., Centeno, Fernando H., Al Mohajer, Mayar, Parkerson, George, Woc-Colburn, Laila, Burgos-Lee, Angelica Janice, Rac, Martha, Dunn, James, Muldrew, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271245/
https://www.ncbi.nlm.nih.gov/pubmed/32547799
http://dx.doi.org/10.1155/2020/6767351
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author Stafford, Irene A.
Centeno, Fernando H.
Al Mohajer, Mayar
Parkerson, George
Woc-Colburn, Laila
Burgos-Lee, Angelica Janice
Rac, Martha
Dunn, James
Muldrew, Kenneth
author_facet Stafford, Irene A.
Centeno, Fernando H.
Al Mohajer, Mayar
Parkerson, George
Woc-Colburn, Laila
Burgos-Lee, Angelica Janice
Rac, Martha
Dunn, James
Muldrew, Kenneth
author_sort Stafford, Irene A.
collection PubMed
description Flea-borne (murine) typhus is caused by Rickettsia typhi. Infection in pregnant women can lead to adverse outcomes when diagnosis and treatment is delayed. We describe how next-generation sequencing (NGS) using the Karius® test was used to rapidly diagnose murine typhus in two pregnant women admitted to a large tertiary care center in Houston, Texas, when all initial testing was nondiagnostic.
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spelling pubmed-72712452020-06-15 Successful Detection of Unrecognized Rickettsia typhi in Pregnancy Using Cell-Free Next-Generation Sequencing Stafford, Irene A. Centeno, Fernando H. Al Mohajer, Mayar Parkerson, George Woc-Colburn, Laila Burgos-Lee, Angelica Janice Rac, Martha Dunn, James Muldrew, Kenneth Case Rep Obstet Gynecol Case Report Flea-borne (murine) typhus is caused by Rickettsia typhi. Infection in pregnant women can lead to adverse outcomes when diagnosis and treatment is delayed. We describe how next-generation sequencing (NGS) using the Karius® test was used to rapidly diagnose murine typhus in two pregnant women admitted to a large tertiary care center in Houston, Texas, when all initial testing was nondiagnostic. Hindawi 2020-05-26 /pmc/articles/PMC7271245/ /pubmed/32547799 http://dx.doi.org/10.1155/2020/6767351 Text en Copyright © 2020 Irene A. Stafford et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Stafford, Irene A.
Centeno, Fernando H.
Al Mohajer, Mayar
Parkerson, George
Woc-Colburn, Laila
Burgos-Lee, Angelica Janice
Rac, Martha
Dunn, James
Muldrew, Kenneth
Successful Detection of Unrecognized Rickettsia typhi in Pregnancy Using Cell-Free Next-Generation Sequencing
title Successful Detection of Unrecognized Rickettsia typhi in Pregnancy Using Cell-Free Next-Generation Sequencing
title_full Successful Detection of Unrecognized Rickettsia typhi in Pregnancy Using Cell-Free Next-Generation Sequencing
title_fullStr Successful Detection of Unrecognized Rickettsia typhi in Pregnancy Using Cell-Free Next-Generation Sequencing
title_full_unstemmed Successful Detection of Unrecognized Rickettsia typhi in Pregnancy Using Cell-Free Next-Generation Sequencing
title_short Successful Detection of Unrecognized Rickettsia typhi in Pregnancy Using Cell-Free Next-Generation Sequencing
title_sort successful detection of unrecognized rickettsia typhi in pregnancy using cell-free next-generation sequencing
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271245/
https://www.ncbi.nlm.nih.gov/pubmed/32547799
http://dx.doi.org/10.1155/2020/6767351
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