Cargando…

A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase

The anaphase‐promoting complex (APC/C) is the key E3 ubiquitin ligase which directs mitotic progression and exit by catalysing the sequential ubiquitination of specific substrates. The activity of the APC/C in mitosis is restrained by the spindle assembly checkpoint (SAC), which coordinates chromoso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alfieri, Claudio, Tischer, Thomas, Barford, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271329/ https://www.ncbi.nlm.nih.gov/pubmed/32307883 http://dx.doi.org/10.15252/embr.201949831

Ejemplares similares

Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C
por: Zhang, Suyang, et al.
Publicado: (2019)

Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation
por: Yatskevich, Stanislau, et al.
Publicado: (2021)

Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)
por: Alfieri, Claudio, et al.
Publicado: (2017)

The APC/C targets the Cep152–Cep63 complex at the centrosome to regulate mitotic spindle assembly
por: Tischer, Thomas, et al.
Publicado: (2022)

BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis
por: Choi, Eunhee, et al.
Publicado: (2009)

Molecular basis of APC/C regulation by the spindle assembly checkpoint
por: Alfieri, Claudio, et al.
Publicado: (2016)

The spindle checkpoint protein Mad2 regulates APC/C activity during prometaphase and metaphase of meiosis I in Saccharomyces cerevisiae
por: Tsuchiya, Dai, et al.
Publicado: (2011)

The APC/C recruits cyclin B1–Cdk1–Cks in prometaphase before D box recognition to control mitotic exit
por: van Zon, Wouter, et al.
Publicado: (2010)

Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain
por: Cronin, Nora B., et al.
Publicado: (2015)

The APC/C Coordinates Retinal Differentiation with G1 Arrest through the Nek2-Dependent Modulation of Wingless Signaling
por: Martins, Torcato, et al.
Publicado: (2017)

PP2A‐B56 binds to Apc1 and promotes Cdc20 association with the APC/C ubiquitin ligase in mitosis
por: Fujimitsu, Kazuyuki, et al.
Publicado: (2019)

Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization
por: Haq, Tamanna, et al.
Publicado: (2015)

An improved method for inducing prometaphase chromosomes in plants
por: Setiawan, Agus Budi, et al.
Publicado: (2018)

The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis
por: Penas, Clara, et al.
Publicado: (2012)

Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor
por: da Fonseca, Paula C.A., et al.
Publicado: (2010)

Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint
por: Wild, Thomas, et al.
Publicado: (2018)

New Functions of APC/C Ubiquitin Ligase in the Nervous System and Its Role in Alzheimer’s Disease
por: Fuchsberger, Tanja, et al.
Publicado: (2017)

An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9
por: Richards, Mark W., et al.
Publicado: (2009)

Mps1 promotes poleward chromosome movements in meiotic prometaphase
por: Meyer, Régis E., et al.
Publicado: (2021)

An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination
por: Zeng, Xing, et al.
Publicado: (2012)

Ubiquitination site preferences in anaphase promoting complex/cyclosome (APC/C) substrates
por: Min, Mingwei, et al.
Publicado: (2013)

The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human Cancers
por: BOCHIS, OVIDIU VASILE, et al.
Publicado: (2015)

Kinase Inhibitor Profile for Human Nek1, Nek6, and Nek7 and Analysis of the Structural Basis for Inhibitor Specificity
por: Moraes, Eduardo Cruz, et al.
Publicado: (2015)

A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
por: Thomas, Christopher, et al.
Publicado: (2021)

Cyclin a Is Destroyed in Prometaphase and Can Delay Chromosome Alignment and Anaphase
por: den Elzen, Nicole, et al.
Publicado: (2001)

NuMA is required for proper spindle assembly and chromosome alignment in prometaphase
por: Haren, Laurence, et al.
Publicado: (2009)

Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma
por: Deng, Ling, et al.
Publicado: (2019)

Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex
por: He, Jun, et al.
Publicado: (2013)

lemmingA encodes the Apc11 subunit of the APC/C in Drosophila melanogaster that forms a ternary complex with the E2-C type ubiquitin conjugating enzyme, Vihar and Morula/Apc2
por: Nagy, Olga, et al.
Publicado: (2012)

Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes
por: Cardozo, Timothy, et al.
Publicado: (2007)

UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
por: Garnett, Mathew J., et al.
Publicado: (2009)

The Anaphase-Promoting Complex (APC) ubiquitin ligase affects chemosensory behavior in C. elegans
por: Wang, Julia, et al.
Publicado: (2016)

APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway
por: Ramanujan, Ajeena, et al.
Publicado: (2016)

The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection
por: Lafranchi, Lorenzo, et al.
Publicado: (2015)

Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint Arrest
por: May, Karen M., et al.
Publicado: (2017)

Three-Dimensional Maps of All Chromosomes in Human Male Fibroblast Nuclei and Prometaphase Rosettes
por: Bolzer, Andreas, et al.
Publicado: (2005)

Heterochromatic Threads Connect Oscillating Chromosomes during Prometaphase I in Drosophila Oocytes
por: Hughes, Stacie E., et al.
Publicado: (2009)

PICH and Cotargeted Plk1 Coordinately Maintain Prometaphase Chromosome Arm Architecture
por: Kurasawa, Yasuhiro, et al.
Publicado: (2010)

R-banding pattern of the prometaphase chromosomes of the domestic sheep Ovis aries L.
por: Di Berardino, D, et al.
Publicado: (1989)

Microtubules assemble near most kinetochores during early prometaphase in human cells
por: Sikirzhytski, Vitali, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_rf06c7b4j8to6ima49jdptlts6