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Anti-inflammatory Withanolides from Physalis minima
[Image: see text] Five new withanolides (1–5) along with five known ones (6–10) were isolated from the whole plants of Physalis minima Linn. The chemical structures of the new compounds were identified as (20S,22R) 15a-acetoxy-5β,6β-epoxy-4β,14a,28-trihydroxy-3β-methoxy-1-oxowitha-16,24-dienolide (1...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271383/ https://www.ncbi.nlm.nih.gov/pubmed/32548395 http://dx.doi.org/10.1021/acsomega.0c00467 |
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author | Wu, Jiangping Zhang, Tao Yu, Meng Jia, Hongmei Zhang, Hongwu Xu, Qiongming Gu, Yucheng Zou, Zhongmei |
author_facet | Wu, Jiangping Zhang, Tao Yu, Meng Jia, Hongmei Zhang, Hongwu Xu, Qiongming Gu, Yucheng Zou, Zhongmei |
author_sort | Wu, Jiangping |
collection | PubMed |
description | [Image: see text] Five new withanolides (1–5) along with five known ones (6–10) were isolated from the whole plants of Physalis minima Linn. The chemical structures of the new compounds were identified as (20S,22R) 15a-acetoxy-5β,6β-epoxy-4β,14a,28-trihydroxy-3β-methoxy-1-oxowitha-16,24-dienolide (1), (20S,22R) 15a-acetoxy-5β,6β-epoxy-3β,4β,14β,17β,20β-pentahydroxy-1-oxowitha-24-enolide (2), (20R,22R) 15α-acetoxy-4β,5α,6β,14α,20β-pentahydroxy-1-oxowitha-2,24-dienolide (3), (20R,22R) 15α-acetoxy-5α,6β,14α,20β-tetrahydroxy-1-oxowitha-2,24-dienolide (4), and (20S,22R) 5α,6β,14β-trihydroxy-1,15-dioxowitha-2,16,24-trienolide (5) on the basis of integration combining IR, UV, HR-ESI-MS, 1D-NMR, and 2D-NMR analyses. Biologically, compounds (1–10) were subjected to evaluate their anti-inflammatory activities via inhibiting nitric oxide production in lipopolysaccharide-stimulated murine RAW 264.7 cells in vitro. The activity screening indicated that all of the compounds showed a moderate inhibitory effect against nitric oxide production with IC(50) values of 23.53–66.28 μM. |
format | Online Article Text |
id | pubmed-7271383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-72713832020-06-15 Anti-inflammatory Withanolides from Physalis minima Wu, Jiangping Zhang, Tao Yu, Meng Jia, Hongmei Zhang, Hongwu Xu, Qiongming Gu, Yucheng Zou, Zhongmei ACS Omega [Image: see text] Five new withanolides (1–5) along with five known ones (6–10) were isolated from the whole plants of Physalis minima Linn. The chemical structures of the new compounds were identified as (20S,22R) 15a-acetoxy-5β,6β-epoxy-4β,14a,28-trihydroxy-3β-methoxy-1-oxowitha-16,24-dienolide (1), (20S,22R) 15a-acetoxy-5β,6β-epoxy-3β,4β,14β,17β,20β-pentahydroxy-1-oxowitha-24-enolide (2), (20R,22R) 15α-acetoxy-4β,5α,6β,14α,20β-pentahydroxy-1-oxowitha-2,24-dienolide (3), (20R,22R) 15α-acetoxy-5α,6β,14α,20β-tetrahydroxy-1-oxowitha-2,24-dienolide (4), and (20S,22R) 5α,6β,14β-trihydroxy-1,15-dioxowitha-2,16,24-trienolide (5) on the basis of integration combining IR, UV, HR-ESI-MS, 1D-NMR, and 2D-NMR analyses. Biologically, compounds (1–10) were subjected to evaluate their anti-inflammatory activities via inhibiting nitric oxide production in lipopolysaccharide-stimulated murine RAW 264.7 cells in vitro. The activity screening indicated that all of the compounds showed a moderate inhibitory effect against nitric oxide production with IC(50) values of 23.53–66.28 μM. American Chemical Society 2020-05-17 /pmc/articles/PMC7271383/ /pubmed/32548395 http://dx.doi.org/10.1021/acsomega.0c00467 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Wu, Jiangping Zhang, Tao Yu, Meng Jia, Hongmei Zhang, Hongwu Xu, Qiongming Gu, Yucheng Zou, Zhongmei Anti-inflammatory Withanolides from Physalis minima |
title | Anti-inflammatory Withanolides from Physalis minima |
title_full | Anti-inflammatory Withanolides from Physalis minima |
title_fullStr | Anti-inflammatory Withanolides from Physalis minima |
title_full_unstemmed | Anti-inflammatory Withanolides from Physalis minima |
title_short | Anti-inflammatory Withanolides from Physalis minima |
title_sort | anti-inflammatory withanolides from physalis minima |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271383/ https://www.ncbi.nlm.nih.gov/pubmed/32548395 http://dx.doi.org/10.1021/acsomega.0c00467 |
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